2-(5-Amino-1,1,1,2,2-pentafluoropentan-3-yl)oxy-6-methylpyridine-3-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(5-Amino-1,1,1,2,2-pentafluoropentan-3-yl)oxy-6-methylpyridine-3-carbonitrile
• 化学式: C₁₂H₁₂F₅N₃O
• 分子量: 309.23
• InChiKey: UZLMEZKUBDBJCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  71.9
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Heteroarylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase
  申请人：——

  公开号：US20040220234A1

  公开（公告）日：2004-11-04

  There are provided novel compounds of formula (I) [Chemical formula should be inserted here. Please see paper copy] wherein R 1 , R 2 , R 3 , T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease, CNS disorders and pain.

  提供了一些新颖的化合物，化学式为(I) [化学式应在此处插入，请查看纸质副本]，其中R1、R2、R3、T、U、X、Y、V和W的定义如规范中所述，以及其药学上可接受的盐；以及它们的制备方法、含有它们的组合物以及它们在治疗中的用途。这些化合物是一氧化氮合酶的抑制剂，因此在治疗或预防炎症性疾病、中枢神经系统疾病和疼痛方面特别有用。
• HETEROARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE
  申请人：AstraZeneca AB

  公开号：EP1421067A1

  公开（公告）日：2004-05-26
• US7119109B2
  申请人：——

  公开号：US7119109B2

  公开（公告）日：2006-10-10
• [EN] HETEROARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE<br/>[FR] DERIVES D'HETEROARYLHETEROALKYLAMINE ET LEUR UTILISATION COMME INHIBITEURS DE LA SYNTHASE D'OXYDE NITRIQUE
  申请人：ASTRAZENECA AB

  公开号：WO2003011831A1

  公开（公告）日：2003-02-13

  There are provided novel compounds of formula (I) [Chemical formula should be inserted here. Please see paper copy] wherein R?1, R2, R3¿, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease, CNS disorders and pain.