3-Chloro-4-(3,4-dichloro-phenylsulfanyl)-phenylamine | 32631-30-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-Chloro-4-(3,4-dichloro-phenylsulfanyl)-phenylamine
• 英文别名: 3-Chloro-4-(3,4-dichlorophenyl)sulfanylaniline
• CAS: 32631-30-4
• 化学式: C₁₂H₈Cl₃NS
• mdl: MFCD21536498
• 分子量: 304.627
• InChiKey: ZLCGBQNOMIJNOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• COMPOUNDS FOR THE MODULATION OF PPARgamma ACTIVITY
  申请人：McGee Lawrence R.

  公开号：US20100113522A1

  公开（公告）日：2010-05-06

  Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.

  提供了PPARγ活性调节剂，可用于制备药物组合物和治疗2型糖尿病和肥胖等疾病的方法。
• INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF
  申请人：ICOS CORPORATION

  公开号：EP1165504A2

  公开（公告）日：2002-01-02
• US7626033B2
  申请人：——

  公开号：US7626033B2

  公开（公告）日：2009-12-01
• US7968567B2
  申请人：——

  公开号：US7968567B2

  公开（公告）日：2011-06-28
• [EN] INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF<br/>[FR] INHIBITEURS DE LA LIAISON DE LFA-1 A DES ICAMS ICAMS ET LIEURS UTILISATIONS
  申请人：ICOS CORP

  公开号：WO2000059878A2

  公开（公告）日：2000-10-12

  The present invention is directed to compounds that bind to a novel regulatory site in the I domain of LFA-1, and thereby inhibit LFA-1 binding to ICAMs that bind LFA-1. The present invention therefore also provides methods to regulate leukocyte adhesion to endothelial cells. Compounds of the ivnention are useful for the treatment of pathologies, such as those associated inflammatory diseases, autoimmune diseases, tumor metastasis, allograft rejection and reperfusion injury. In particular, the present invention is directed to diaryl sulfides of general structural formula (I), a pharmaceutically acceptable salt, or prodrug thereof, and to the use of diaryl sulfides, and particularly compounds of formula (I), to inhibit LFA-1 binding to an ICAM that binds LFA-1 wherein A and B, independently, are aryl groups selected from the group consisting of 5- and 6-membered aromatic rings, including, but not limited to, phenyl, thienyl, furyl, pyrimidinyl, imidazolyl, pyrazolyl, pyridyl, pyrazinyl, pyrrolyl, and pyridazinyl.