N-[1-(furan-2-yl)ethyl]-N-pyridin-4-yladamantane-1-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-[1-(furan-2-yl)ethyl]-N-pyridin-4-yladamantane-1-carboxamide
• 化学式: C₂₂H₂₆N₂O₂
• 分子量: 350.461
• InChiKey: IDHJGHADFUJOMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  46.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PROTEIN CRYSTAL
  申请人：KARO BIO AB

  公开号：EP1583776A2

  公开（公告）日：2005-10-12
• Protein crystal
  申请人：Farnegardh Mathias

  公开号：US20070060740A1

  公开（公告）日：2007-03-15

  The present invention is in the fields of biotechnology, protein purification and crystallization, x-ray diffraction analysis, three-dimensional computer molecular modelling and rational drug design. The invention is directed to the Liver X receptor and ligands for this receptor, and in particular to crystalline Liver X receptor beta (LXRβ) and to methods of identifying ligands utilizing LXRβ, as well as to compounds, compositions and methods for selecting, making, and using therapeutic or diagnostic agents having LXRβ modulating or binding activity.
• [EN] PROTEIN CRYSTAL<br/>[FR] CRISTAL DE PROTÉINE
  申请人：KAROBIO AB

  公开号：WO2004058819A2

  公开（公告）日：2004-07-15

  The present invention is in the fields of biotechnology, protein purification and crystallization, x-ray diffraction analysis, three-dimensional computer molecular modelling and rational drug design. The invention is directed to the Liver X receptor and ligands for this receptor, and in particular to crystalline Liver X receptor beta (LXRβ) and to methods of identifying ligands utilizing LXRβ, as well as to compounds, compositions and methods for selecting, making, and using therapeutic or diagnostic agents having LXRβ modulating or binding activity.