3-({3-[4-(Biphenyl-4-yloxy)-phenoxy]-propyl}-methyl-amino)-propionic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-({3-[4-(Biphenyl-4-yloxy)-phenoxy]-propyl}-methyl-amino)-propionic acid
• 英文别名: 3-[methyl-[3-[4-(4-phenylphenoxy)phenoxy]propyl]amino]propanoic acid
• 化学式: C₂₅H₂₇NO₄
• 分子量: 405.5
• InChiKey: WXPJULBDMSVCLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A LEUKOTRIENE A4 HYDROLASE INHIBITOR<br/>[FR] COMPOSITIONS COMPRENANT UN INHIBITEUR DE CYCLOOXYGENASE-2 ET UN INHIBITEUR DE LEUCOTRIENE A4 HYDROLASE
  申请人：G.D. SEARLE & CO.

  公开号：WO1996041625A1

  公开（公告）日：1996-12-27

  (EN) Combinations of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor are described for treatment of inflammation and inflammation-related disorders.(FR) Combinaisons d'un inhibiteur de cyclooxygénase-2 et d'un inhibiteur de leucotriène A4 hydrolase utilisées pour traiter l'inflammation et les troubles associés à l'inflammation.

  这是一种使用环氧合酶-2抑制剂和白三烯A4水解酶抑制剂的组合，用于治疗炎症和与炎症相关的疾病。
• Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
  申请人：Pharmacia Corporation

  公开号：US20030004191A1

  公开（公告）日：2003-01-02

  Treatment with a cyclooxygenase-2 inhibitor and a leukotriene A 4 hydrolase inhibitor is described as being useful in reducing recipient rejection of transplanted organs and for treatment of autoimmune diseases.

  使用环氧化酶-2抑制剂和白三烯A4水解酶抑制剂的治疗被描述为减少移植器官受体排斥和治疗自身免疫性疾病的有用方法。
• Methods of preventing or treating recurrence of myocardial infarction
  申请人：Helgadottir Anna

  公开号：US20050272051A1

  公开（公告）日：2005-12-08

  Linkage of myocardial infarction (MI) with a locus on chromosome 12q23 is disclosed. In particular, the LTA4H gene within this locus is shown by association analysis to be a susceptibility gene for MI. Methods for preventing and/or treating the recurrence of MI, in particular are described.

  本研究揭示了心肌梗塞（MI）与染色体 12q23 上一个基因座的联系。特别是，通过关联分析表明，该基因座上的 LTA4H 基因是心肌梗塞的易感基因。特别描述了预防和/或治疗心肌梗塞复发的方法。
• Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
  申请人：Helgadottir Anna

  公开号：US20060019269A1

  公开（公告）日：2006-01-26

  Linkage of myocardial infarction (MI) and a locus on chromosome 13q12 is disclosed. In particular, the FLAP gene within this locus is shown by genetic association analysis to be a susceptibility gene for MI and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described. The invention also provides for compositions comprising a leukotriene synthesis inhibitor and a stating and methods of using these compositions to reduce C-reactive protein in a human subject at risk of MI, ACS, stroke and/or PAOD.

  本研究揭示了心肌梗塞（MI）与染色体 13q12 上一个位点的联系。特别是，遗传关联分析表明，该基因座上的 FLAP 基因是心肌梗死和急性心肌梗死以及中风和 PAOD 的易感基因。本发明描述了用于治疗和诊断的靶向途径，特别是用于识别有患心肌梗死、心肌梗死综合症、中风或 PAOD 风险的人群。本发明还提供了包含白三烯合成抑制剂和说明的组合物，以及使用这些组合物降低有MI、ACS、中风和/或PAOD风险的人体内C反应蛋白的方法。
• COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A LEUKOTRIENE A 4 HYDROLASE INHIBITOR
  申请人：G.D. Searle & Co.

  公开号：EP0843549B1

  公开（公告）日：2006-04-12