N-[3,5-dichloro-4-(4-hydroxy-3-isopropyl-phenoxy)-2-methyl-phenyl]-malonamic acid | 355129-17-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3,5-dichloro-4-(4-hydroxy-3-isopropyl-phenoxy)-2-methyl-phenyl]-malonamic acid
• 英文别名: 3-[3,5-Dichloro-4-(4-hydroxy-3-propan-2-ylphenoxy)-2-methylanilino]-3-oxopropanoic acid
• CAS: 355129-17-8
• 化学式: C₁₉H₁₉Cl₂NO₅
• 分子量: 412.27
• InChiKey: VGLJPOKNYGLDTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Process for the preparation of aniline-derived thyroid receptor ligands
  申请人：——

  公开号：US20030157671A1

  公开（公告）日：2003-08-21

  Provided are processes for the synthesis of aniline derivatives, specifically certain aniline derivatives which have activity as thyroid receptor ligands.

  提供了合成苯胺衍生物的过程，具体来说是具有甲状腺受体配体活性的某些苯胺衍生物。
• ANILINE-DERIVED LIGANDS FOR THE THYROID RECEPTOR
  申请人：Bristol-Myers Squibb Company

  公开号：EP1257526B1

  公开（公告）日：2005-05-11
• Aniline-derived ligands for the thyroid receptor
  申请人：Friends J. Todd

  公开号：US20050032890A1

  公开（公告）日：2005-02-10

  New thyroid receptor ligands are provided which have the general formula in which: X is —O—, —S—, —CH 2 —, —CO—, or —NH—; Y is —(CH 2 ) n — where n is an integer from 1 to 5, or cis- or trans-ethylene; R 1 is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R 2 and R 3 are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 6 carbons, at least one of R 2 and R 3 being other than hydrogen; R 4 is hydrogen or lower alkyl; R 5 is hydrogen or lower alkyl; R 6 is carboxylic acid, or esters or prodrugs; R 7 is hydrogen or an alkanoyl or an aroyl. In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependent upon the expression of a T 3 regulated gene, wherein a compound as described above is administered in a therapeutically effective amount. Examples of such diseases associated with metabolism dysfunction or are dependent upon the expression of a T 3 regulated gene include obesity, hypercholesterolemia, atherosclerosis, cardiac arrhythmias, depression, osteoporosis, hypothyroidism, goiter, thyroid cancer as well as glaucoma, congestive heart failure and skin disorders.
• US6806381B2
  申请人：——

  公开号：US6806381B2

  公开（公告）日：2004-10-19
• US7109164B2
  申请人：——

  公开号：US7109164B2

  公开（公告）日：2006-09-19