2-chloro-N-[(1-ethylpiperidin-2-yl)-phenylmethyl]-3-(trifluoromethyl)benzamide;hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-N-[(1-ethylpiperidin-2-yl)-phenylmethyl]-3-(trifluoromethyl)benzamide;hydrochloride
• 化学式: C22H25Cl2F3N2O
• 分子量: 461.3
• InChiKey: XHTFOMZUUJZKNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.13
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Derivative of n-[phenyl(piperidin-2-yl)methyl]benzamide, the preparation method thereof and application of same in therapeutics
  申请人：Dargazanli Gihad

  公开号：US20050159450A1

  公开（公告）日：2005-07-21

  Compound of general formula (I) in which A represents either a group of formula N—R 1 in which R 1 represents a hydrogen atom, an alkyl group, a cycloalkyl group, a phenylalkyl group, an alkenyl group or an alkynyl group, or a group of formula N + (O − )R 1 in which R 1 is as defined above, or alternatively a group of formula N + (R′)R 1 in which R′ represents an alkyl group and R 1 is as defined above, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, R 2 represents a hydrogen atom, one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, amino groups of formula NR 3 R 4 in which R 3 and R 4 each represent a hydrogen atom or an alkyl group, or form with the nitrogen atom carrying them a pyrrolidine, piperidine or morpholine ring, or an optionally substituted phenyl group. Application in therapy.

  通式（I）的化合物，其中A代表以下两种情况之一：具有N—R1的化学式的基团，其中R1代表氢原子、烷基基团、环烷基基团、苯基烷基基团、烯基基团或炔基基团，或具有N+(O−)R1的化学式的基团，其中R1如上定义，或者具有N+(R′)R1的化学式的基团，其中R′代表烷基基团，R1如上定义；X代表氢原子或来自卤素原子、三氟甲基、烷基和烷氧基的一个或多个取代基；R2代表氢原子、来自卤素原子、三氟甲基、烷基和烷氧基的一个或多个取代基，具有以下基团的氨基：NR3R4，其中R3和R4各自代表氢原子或烷基基团，或者与携带它们的氮原子形成吡咯烷、哌啶或吗啉环，或者是一个可选择取代的苯基基团。在治疗中的应用。
• Use of N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives in therapy
  申请人：DARGAZANLI Gihad

  公开号：US20070197601A1

  公开（公告）日：2007-08-23

  The present invention discloses and claims therapeutic use of a series of compounds of general formula (I) in which A, X and R 2 are as described herein. Specifically, the compounds of formula (I) exhibit a particular activity as specific inhibitors of the glycine transporters glyt1 and/or glty2.

  本发明揭示和声明了一系列通式(I)的化合物的治疗用途，其中A、X和R2如本文所述。具体而言，通式(I)的化合物表现出一种特定的活性，作为甘氨酸转运体glyt1和/或glyt2的特异性抑制剂。
• DERIVES DE N-¬PHENYL(PIPERIDIN-2-YL)METHYL|BENZAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
  申请人：Sanofi-Aventis

  公开号：EP1499589B1

  公开（公告）日：2007-05-02
• US7326722B2
  申请人：——

  公开号：US7326722B2

  公开（公告）日：2008-02-05