2-Dimethylamino-ethyl (RS)-2-(2,6-dichlorophenyl)-5-(2-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Dimethylamino-ethyl (RS)-2-(2,6-dichlorophenyl)-5-(2-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate
• 英文别名: 2-(2,6-Dichloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester；2-(dimethylamino)ethyl 2-(2,6-dichlorophenyl)-5-(2-methoxyphenyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
• 化学式: C₂₅H₂₅Cl₂N₃O₃S
• 分子量: 518.464
• InChiKey: GBPBWQGPBSYBOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  79.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  α-bromo-2,6-dichlorophenyl-acetaldehyde 、 4-(2-Methoxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-dimethylamino-ethyl ester 以 乙腈 为溶剂， 生成 2-Dimethylamino-ethyl (RS)-2-(2,6-dichlorophenyl)-5-(2-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate
  参考文献：
  名称：

  Structure-activity relationships of substituted 5H-thiazolo[3,2-a]pyrimidines as group 2 metabotropic glutamate receptor antagonists

  摘要：

  A series of 5H-thiazolo[3,2-a]pyrimidine derivatives 1 was studied with respect to the inhibition of 1S,3R-ACPD (10 mu M)-stimulated GTP gamma(35)S binding on rat mGlu2 receptor transfected cell membranes. The influence of substituents at position 6 and 7 as well as the substitution pattern of the two phenyl-rings in position 2 and 5 on the activity is discussed. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00227-9

文献信息

• US5958931
  申请人：——

  公开号：——

  公开（公告）日：——
• 5H-Thiazolo (3,2-a) pyrimidine derivatives
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0891978B1

  公开（公告）日：2002-03-20
• JPH1171380A
  申请人：——

  公开号：JPH1171380A

  公开（公告）日：1999-03-16
• Structure-activity relationships of substituted 5H-thiazolo[3,2-a]pyrimidines as group 2 metabotropic glutamate receptor antagonists
  作者：Jürgen Wichmann、Geo Adam、Sabine Kolczewski、Vincent Mutel、Thomas Woltering

  DOI：10.1016/s0960-894x(99)00227-9

  日期：1999.6

  A series of 5H-thiazolo[3,2-a]pyrimidine derivatives 1 was studied with respect to the inhibition of 1S,3R-ACPD (10 mu M)-stimulated GTP gamma(35)S binding on rat mGlu2 receptor transfected cell membranes. The influence of substituents at position 6 and 7 as well as the substitution pattern of the two phenyl-rings in position 2 and 5 on the activity is discussed. (C) 1999 Elsevier Science Ltd. All rights reserved.