methyl N-[4-[3-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]-1-[4-(methoxycarbonylamino)phenyl]propyl]phenyl]carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl N-[4-[3-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]-1-[4-(methoxycarbonylamino)phenyl]propyl]phenyl]carbamate
• 化学式: C₂₈H₃₃N₃O₇
• 分子量: 523.6
• InChiKey: KCXVGRAGFKJMDT-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  38
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  138
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• [EN] AMINOALCOHOL DERIVATIVES AND THEIR USE AS BETA 3 ADRENERGIC AGONISTS<br/>[FR] DERIVES AMINO-ALCOOL
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2002036552A1

  公开（公告）日：2002-05-10

  The present invention relates to a compound of formula (I) wherein R1 is hydrogen or a hydroxy protective group, R2 is hydrogen or an amino protective group, R3 is lower alkoxycarbonylamino, and R4 is lower alkoxycarbonylamino, or a salt thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.