N-[4-[4-(1-phenyl-2-pyrazol-1-ylethyl)piperazin-1-yl]phenyl]-2-[4-(trifluoromethyl)phenyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-[4-(1-phenyl-2-pyrazol-1-ylethyl)piperazin-1-yl]phenyl]-2-[4-(trifluoromethyl)phenyl]benzamide
• 化学式: C₃₅H₃₂F₃N₅O
• 分子量: 595.7
• InChiKey: DYADRRHEEFJZRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  44
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  53.4
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• BENZAMIDE DERIVATIVES AND THEIR USE AS APOB-100 AND MTP INHIBITORS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1289971A1

  公开（公告）日：2003-03-12
• [EN] BENZAMIDE DERIVATIVES AND THEIR USE AS APOB-100 AND MTP INHIBITORS<br/>[FR] DERIVES DE BENZAMIDE ET LEUR UTILISATION COMME INHIBITEURS D'APOB-100 ET DE MTP
  申请人：GLAXO GROUP LTD

  公开号：WO2001092241A1

  公开（公告）日：2001-12-06

  The present invention relates to a compound of formula (I); wherein R1 represents isopropyl or trifluoromethyl; R2 represents hydrogen, C¿1-4?alkyl, chloro, fluoro or trifluoromethyl; R?3¿ represents(i) phenyl, optionally substituted by cyano, halogen, trifluoromethyl or an optionally substituted 5-membered heteroaromatic group, where optional substitution is effected by C¿1-4?alkyl, (ii) a 5- membered heteroaromatic group, optionally substituted by halogen, cyano or C1-4alkyl, (iii) aminocarbonyl, or(iv) ethyl or eth-1-enyl; R?4¿ represents cyano, methyl, acetyl, a 5- membered heteroaromatic group, optionally substituted by C¿1-4?alkyl or phenyl, or a group X-Y-Z; X represents a carboxy, oxo, C1-6alkylene, carboxamido or thiocarboxamido linking group; Y represents a direct link or C1-6alkylene; Z represents (i) hydrogen, (ii) trifluoromethyl, (iii) cyano, (iv) phenyl, (v) a 5- or 6- membered heteroaromatic group, optionally substituted by C1-4alkyl, with the proviso that when X represents C1-4alkylene, Y and Z do not represent a direct link and hydrogen respectively, or when X represents oxo, Y and Z do not represent C1-6alkylene and hydrogen respectively; or a physiologically acceptable salt, solvate or derivative thereof, to compositions comprising the compound, processes for their preparation and their use in treating conditions ameliorated by an apoB-100 and/or MTP inhibitor.