Phenyl 3-hydroxypyrrolidine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Phenyl 3-hydroxypyrrolidine-1-carboxylate
• 化学式: C₁₁H₁₃NO₃
• 分子量: 207.23
• InChiKey: CWYJQAWUCDXWLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Process for preparing optically active 3-hydroxypyrrolidine derivatives by enzymatic hydroxylation
  申请人：——

  公开号：US20030219883A1

  公开（公告）日：2003-11-27

  A process for the preparation of optically active 3-hydroxypyrrolidine or N-substituted 3-hydroxypyrrolidines, wherein an oxygen atom is inserted stereoselectively into the corresponding pyrrolidines, respectively, by use of a bacterium having hydroxylation activity, or a prokaryotic host-organism having the gene(s) necessary for the hydroxylation, or an enzyme having hydroxylation activity derived therefrom. The bacterium may be selected from strains having alkane hydroxylases, strains degrading alkanes or mono-alicyclic compounds, or strains from the genera Pseudomonas, Mycobacterium, Corynebacterium, Nocardia, Sphingomonas, Gordona, Rhodococcus, Bacillus, Streptomyces; Sebekia and Methylococcus.

  一种制备光学活性3-羟基吡咯烷或N-取代的3-羟基吡咯烷的过程，其中通过使用具有加氢活性的细菌或具有必要基因的原核生物宿主或源自其的加氢酶，将氧原子立体选择性地插入相应的吡咯烷中。细菌可以从具有烷基加氢酶、降解烷烃或单环萜化合物、或来自假单胞菌、分枝杆菌、诺卡氏菌、星状杆菌、戈多纳菌、红球菌、芽孢杆菌、链霉菌、塞贝基亚和甲烷菌属的菌株中选择。
• PROCESS FOR PREPARING OPTICALLY ACTIVE 3-HYDROXY-PYRROLIDINE DERIVATIVES BY ENZYMATIC HYDROXYLATION
  申请人：——

  公开号：US20020106763A1

  公开（公告）日：2002-08-08

  A process for the preparation of optically active 3-hydroxypyrrolidine or N-substituted 3-hydroxypyrrolidines, wherein an oxygen atom is inserted stereoselectively into the corresponding pyrrolidines, respectively, by use of a bacterium having hydroxylation activity, or a prokaryotic host-organism having the gene(s) necessary for the hydroxylation, or an enzyme having hydroxylation activity derived therefrom. The bacterium may be selected from strains having alkane hydroxylases, strains degrading alkanes or mono-alicyclic compounds, or strains from the genera Pseudomonas, Mycobacterium, Corynebacterium, Nocardia, Sphingomonas, Cordona, Rhodococcus, Bacillus, Streptomyces, Sebekia and Methylococcus.

  一种制备光学活性3-羟基吡咯烷或N-取代的3-羟基吡咯烷的方法，其中通过使用具有羟化活性的细菌或具有羟化所需基因的原核生物宿主或源自其的羟化酶，分别将氧原子立体选择性地插入相应的吡咯烷中。细菌可以从具有烷烃羟化酶、降解烷烃或单环烃化合物的菌株中选择，或从假单胞菌属、分枝杆菌属、诺卡氏菌属、Sphingomonas属、Cordona属、红球菌属、链霉菌属、Sebekia属和Methylococcus属中选择。
• Process for preparing n-substituted 4-hydroxypiperidines by enzymatic hudroxylation
  申请人：——

  公开号：US20040029237A1

  公开（公告）日：2004-02-12

  A process for the preparation of N-substituted 4-hydroxypiperidine, wherein an oxygen atom is inserted regioselectively into the corresponding N-substituted piperidine, by using as a biocatalyst a bacterium degrading alkanes or alicyclic hydrocarbons, or a prokaryotic host-organism having the gene(s) necessary for the hydroxylation derived from the said bacterium, or an enzyme having hydroxylation activity derived therefrom. The bacterium may be selected from species from, for example, the genera Sphingomonas and Pseudomonas, that are capable of degrading n-alkanes having 4 to 20 carbon atoms.

  一种制备N-取代4-羟基哌啶的方法，其中通过使用降解脂肪烃或脂环烃的细菌作为生物催化剂，或具有来自该细菌的羟化所需基因的原核生物宿主-有机体，或具有羟化活性的酶，将氧原子选择性地插入相应的N-取代哌啶中。细菌可以从Sphingomonas和Pseudomonas等属的物种中选择，这些物种能够降解具有4到20个碳原子的n-烷烃。
• Process for preparing N-substituted 4-hydroxypiperidines by enzymatic hydroxylation
  申请人：Eidgenössische Technische Hochschule Zürich

  公开号：EP1188837A1

  公开（公告）日：2002-03-20

  A process for the preparation of N-substituted 4-hydroxypiperidine, wherein an oxygen atom is inserted regioselectively into the corresponding N-substituted piperidine, by using as a biocatalyst a bacterium degrading alkanes or alicyclic hydrocarbons, or a prokaryotic host-organism having the gene(s) necessary for the hydroxylation derived from the said bacterium, or an enzyme having hydroxylation activity derived therefrom. The bacterium may be selected from species from, for example, the genera Sphingomonas and Pseudomonas, that are capable of degrading n-alkanes having 4 to 20 carbon atoms.

  一种制备 N-取代的 4-羟基哌啶的工艺，其中氧原子被选择性地插入到相应的 N-取代的哌啶中，制备方法是使用降解烷烃或脂环烃的细菌作为生物催化剂，或使用原核宿主生物，该宿主生物具有羟基化所需的基因，该基因来自上述细菌，或具有羟基化活性的酶，该酶来自上述细菌。该细菌可选自能够降解 4 至 20 个碳原子的正烷烃的鞘氨单胞菌属和假单胞菌属等菌种。
• PROCESS FOR PREPARING OPTICALLY ACTIVE 3-HYDROXY-PYRROLIDINE DERIVATIVEES BY ENZYMATIC HYDROXYLATION
  申请人：Eidgenössische Technische Hochschule Zürich

  公开号：EP1131460A1

  公开（公告）日：2001-09-12