1,3-Bis[(6-chloropyridin-3-yl)methyl]imidazol-2-imine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,3-Bis[(6-chloropyridin-3-yl)methyl]imidazol-2-imine
• 化学式: C₁₅H₁₃Cl₂N₅
• 分子量: 334.2
• InChiKey: KOFZBXNQANFDPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  56.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Di-substituted imineheterocyclic compounds
  申请人：——

  公开号：US20030078259A1

  公开（公告）日：2003-04-24

  There is provided di-substituted iminoheterocyclic compounds of the following formula (I): 1 in which, A is optionally substituted alkyl group, optionally substituted aryl group or optionally substituted heterocyclic group; X is oxygen atom, sulfur atom, carbon atom or nitrogen atom; the group —X—Y— represents optionally substituted alkylene or cyclic alkenylene bond; and B 1 and B 2 are, hydrogen atom, optionally substituted alkyl group, optionally substituted aryl group or optionally substituted heterocyclic group, independent from each other, or a pharmaceutically acceptable salt thereof. These compounds have good affinity for &agr;4&bgr;2 nicotinic acetylcholine receptors and activate the same to thereby exert a preventive or therapeutic effect on cerebral dysfunction.

  提供以下式(I)的二取代亚胺杂环化合物：其中，A是可选取代的烷基、芳基或杂环基；X是氧原子、硫原子、碳原子或氮原子；—X—Y—基团表示可选取代的烷基或环烯基键；B1和B2是氢原子、可选取代的烷基、芳基或杂环基，彼此独立，或其药学上可接受的盐。这些化合物具有良好的α4β2烟碱性乙酰胆碱受体亲和力，并激活该受体，从而对脑功能障碍产生预防或治疗作用。
• DI-SUBSTITUTED IMINOHETEROCYCLIC COMPOUNDS
  申请人：SUNTORY LIMITED

  公开号：EP1218371A2

  公开（公告）日：2002-07-03
• US6900202B2
  申请人：——

  公开号：US6900202B2

  公开（公告）日：2005-05-31
• [EN] DI-SUBSTITUTED IMINOHETEROCYCLIC COMPOUNDS<br/>[FR] COMPOSES IMINOHETEROCYCLIQUES DISUBSTITUES
  申请人：SUNTORY LTD

  公开号：WO2001070733A2

  公开（公告）日：2001-09-27

  There is provided di-substituted iminoheterocyclic compounds of the formula (I) in which, A is optionally substituted alkyl group, optionally substituted aryl group or optionally substituted heterocyclic group; X is oxygen atom, sulfur atom, carbon atom or nitrogen atom;the group -X-Y- represents optionally substituted alkylene or cyclic alkenylene bond; and B?1 and B2¿ are, hydrogen atom, optionally substituted alkyl group, optionally substituted aryl group or optionally substituted heterocyclic group, independent from each other, or a pharmaceutically acceptable salt thereof. These compounds have good affinity for (α4β2 nicotinic acetylcholine receptors and activate the same to thereby exert a preventive or therapeutic effect on cerebral dysfunction.