ethyl (2E,4E)-6-(2,5-dimethoxyphenyl)-6-oxo-3-propylhexa-2,4-dienoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl (2E,4E)-6-(2,5-dimethoxyphenyl)-6-oxo-3-propylhexa-2,4-dienoate
• 化学式: C₁₉H₂₄O₅
• 分子量: 332.4
• InChiKey: BUIGHGZAIYRNRB-SHQVAAIUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] NOVEL SUBSTITUTED ARYLHEXADIENOIC ACIDS AND ESTERS THEREOF WHICH CAN BE USED FOR THE TREATMENT AND PREVENTION OF DIABETES, DYSLIPIDAEMIA AND ATHEROSCLEROSIS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PROCESSES FOR THE PREPARATION OF THEM<br/>[FR] NOUVEAUX ACIDES ARYL-HEXADIENOIQUES SUBSTITUES ET LEURS ESTERS POUVANT ETRE UTILISES POUR LE TRAITEMENT ET LA PREVENTION DU DIABETE, DE LA DYSLIPIDEMIE ET DE L'ATHEROSCLEROSE, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET PROCEDES DE PREPARATION
  申请人：MERCK PATENT GMBH

  公开号：WO2004031116A1

  公开（公告）日：2004-04-15

  The invention relates to compounds of the formula (I), and to the pharmaceutically acceptable salts thereof, to processes for the preparation of them and to pharmaceutical compositions comprising them, which are useful especially for the treatment and prevention of dyslipidaemia, atherosclerosis and diabetes.

  该发明涉及公式(I)的化合物，以及其药用可接受的盐，用于制备它们的方法和包含它们的药物组合物，这些化合物特别适用于治疗和预防脂质代谢异常、动脉粥样硬化和糖尿病。
• Novel substituted arylhexadienoic acids and esters thereof which can be used for the treatment and prevention of diabetes, dyslipidaemia and atherosclerosis, pharmaceutical compositios comprising them and processes for the preparation of them
  申请人：Brunet Michel

  公开号：US20060052447A1

  公开（公告）日：2006-03-09

  The invention relates to compounds of the formula I: and to the pharmaceutically acceptable salts thereof, to processes for the preparation of them and to pharmaceutical compositions comprising them, which are useful especially for the treatment and prevention of dyslipidaemia, atherosclerosis and diabetes.

  本发明涉及公式I的化合物及其药学上可接受的盐，制备它们的方法和包含它们的制药组合物，特别适用于治疗和预防血脂异常、动脉粥样硬化和糖尿病。
• NOVEL SUBSTITUTED ARYLHEXADIENOIC ACIDS AND ESTERS THEREOF WHICH CAN BE USED FOR THE TREATMENT AND PREVENTION OF DIABETES, DYSLIPIDAEMIA AND ATHEROSCLEROSIS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PROCESSES FOR THE PREPARATION OF THEM
  申请人：MERCK PATENT GmbH

  公开号：EP1546083A1

  公开（公告）日：2005-06-29
• US7737176B2
  申请人：——

  公开号：US7737176B2

  公开（公告）日：2010-06-15