1-[4-chloro-3-(trifluoromethyl)phenyl]-3-(1H-indazol-5-yl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-(1H-indazol-5-yl)urea
• 化学式: C₁₅H₁₀ClF₃N₄O
• 分子量: 354.71
• InChiKey: AZOGXRDZRQCPJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  69.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Urea derivatives
  申请人：Yura Takeshi

  公开号：US20050119304A1

  公开（公告）日：2005-06-02

  A medicament which contains a urea derivative or a salt thereof as an active ingredient is disclosed. The medicament has an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence and/or inflammatory disorders.

  本发明揭示了一种含有尿素衍生物或其盐作为活性成分的药物。该药物具有优异的VR1拮抗剂活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗尿急性尿失禁、过度活动膀胱、慢性疼痛、神经痛、术后疼痛、类风湿性关节炎疼痛、神经痛、神经病、疼痛、神经损伤、缺血、神经退行性疾病、中风、失禁和/或炎症性疾病。
• UREA DERIVATIVES
  申请人：Bayer HealthCare AG

  公开号：EP1465623A1

  公开（公告）日：2004-10-13
• [EN] UREA DERIVATIVES<br/>[FR] DERIVES D'UREE
  申请人：BAYER AG

  公开号：WO2003055484A1

  公开（公告）日：2003-07-10

  A medicament which contains a urea derivative or a salt thereof as an active ingredient is disclosed. The medicament has an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence and/or inflammatory disorders.