Ethanol;1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Ethanol;1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea
• 化学式: C18H26N4O4S
• 分子量: 394.5
• InChiKey: DXRQJPLUUAFSMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.53
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Method for the Preparation of Crystal Forms of Torsemide in a Pure State
  申请人：Welzig Stefan

  公开号：US20070260068A1

  公开（公告）日：2007-11-08

  A method for the preparation of crystal form 1 of polymorphous crystalline torsemide, wherein torsemide is dissolved in an ethanol-water mixture with heating, after which the torsemide is subsequently cooled and dried once crystal separation has been performed. Drying takes place in a blade drier, for example, with the crystals being subjected to mechanical stress, wherein the crystals of crystalline form 2 are transformed into crystalline form 1.

  一种制备多形结晶托瑟米特的晶体形式1的方法，其中托瑟米特在乙醇-水混合物中加热溶解，随后在晶体分离后进行冷却和干燥。干燥在刮刀干燥器中进行，晶体受到机械应力作用，其中晶体形式2的晶体转化为晶体形式1。
• TORSEMIDE POLYMORPHS
  申请人：TEVA PHARMACEUTICAL INDUSTRIES LTD.

  公开号：EP1207880A1

  公开（公告）日：2002-05-29
• EP1207880A4
  申请人：——

  公开号：EP1207880A4

  公开（公告）日：2004-09-01
• US6465496B1
  申请人：——

  公开号：US6465496B1

  公开（公告）日：2002-10-15
• [EN] TORSEMIDE POLYMORPHS<br/>[FR] POLYMORPHES DE TORSEMIDE
  申请人：TEVA PHARMA

  公开号：WO2001010441A1

  公开（公告）日：2001-02-15

  The present invention is directed to the novel forms of torsemide, designated Form V, amorphous torsemide, Dupont Form 2 solvent adduct, Dupont Form 2 ethanol adduct and Dupont Form 2 isopropanol adduct. Methods for their preparation are also disclosed. The present invention also relates to processes for making torsemide modification (I). Pharmaceutical compositions containing the new forms of torsemide and methods of using them are also disclosed.