7-(2-chloro-6-fluorobenzyl)-1,3-diethyl-8-piperidin-1-yl-3,7-dihydro-1H-purine-2,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-(2-chloro-6-fluorobenzyl)-1,3-diethyl-8-piperidin-1-yl-3,7-dihydro-1H-purine-2,6-dione
• 英文别名: 7-[(2-Chloro-6-fluorophenyl)methyl]-1,3-diethyl-8-piperidin-1-ylpurine-2,6-dione
• 化学式: C₂₁H₂₅ClFN₅O₂
• 分子量: 433.913
• InChiKey: WLOOSHJQLURHFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  61.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Purine derivatives as liver x receptor agonists
  申请人：Boggs Davis Sharon

  公开号：US20060094733A1

  公开（公告）日：2006-05-04

  The invention relates to methods for the treatment or prevention of an LXR mediated disease or condition, including cardiovascular disease and atherosclerosis, novel compounds for use in such methods and pharmaceutical compositions comprising compounds for use in such methods.

  本发明涉及用于治疗或预防LXR介导的疾病或病况的方法，包括心血管疾病和动脉粥样硬化，用于此类方法的新化合物以及包含用于此类方法的化合物的药物组合物。
• Methods and compositions to promote bone homestasis
  申请人：Van Rompaey Luc

  公开号：US20060020036A1

  公开（公告）日：2006-01-26

  The present invention relates to a method for promoting osteogenesis by contacting osteoblast progenitor cells with an LXR agonist. Said method is useful for the treatment or prevention of an imbalance in bone homeostasis in a subject using bone homeostasis-promoting compositions comprising an effective osteogenic stimulating amount of an LXR agonist in admixture with a pharmaceutically acceptable carrier. A further aspect is a method to produce bone tissue in vitro by contacting an LXR agonist with a population of osteoblast progenitor cells on a substrate, for a time sufficient to stimulate the generation of a matrix of bone tissue.

  本发明涉及一种通过使成骨细胞祖细胞与 LXR 激动剂接触来促进成骨的方法。所述方法可用于使用骨平衡促进组合物治疗或预防受试者骨平衡失调，该组合物包含有效成骨刺激量的 LXR 激动剂，并与药学上可接受的载体混合。另一个方面是一种体外生成骨组织的方法，其方法是将 LXR 激动剂与基质上的成骨祖细胞群接触，接触时间足以刺激骨组织基质的生成。
• LXR AGONISTS TO PROMOTE BONE HOMEOSTASIS
  申请人：Galapagos N.V.

  公开号：EP1758651A2

  公开（公告）日：2007-03-07
• US7495004B2
  申请人：——

  公开号：US7495004B2

  公开（公告）日：2009-02-24
• [EN] METHODS AND COMPOSITIONS TO PROMOTE BONE HOMEOSTASIS<br/>[FR] PROCEDES ET COMPOSITIONS PERMETTANT DE FAVORISER L'HOMEOSTASIE OSSEUSE
  申请人：GALAPAGOS GENOMICS NV

  公开号：WO2006000577A2

  公开（公告）日：2006-01-05

  The present invention relates to a method for promoting osteogenesis by contacting osteoblast progenitor cells with an LXR agonist. Said method is useful for the treatment or prevention of an imbalance in bone homeostasis in a subject using bone homeostasis-promoting compositions comprising an effective osteogenic stimulating amount of an LXR agonist in admixture with a pharmaceutically acceptable carrier. A further aspect is a method to produce bone tissue in vitro by contacting an LXR agonist with a population of osteoblast progenitor cells on a substrate, for a time sufficient to stimulate the generation of a matrix of bone tissue.