2-[3-[4-[[4-(2,3-Difluorophenyl)-2,5-dioxopyrrol-3-yl]amino]phenyl]sulfanylphenyl]acetic acid

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-[3-[4-[[4-(2,3-Difluorophenyl)-2,5-dioxopyrrol-3-yl]amino]phenyl]sulfanylphenyl]acetic acid
• 化学式: C₂₄H₁₆F₂N₂O₄S
• 分子量: 466.5
• InChiKey: FZUAOYCKHMAJPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• [EN] PYRROLE-2,5-DIONE DERIVATIVES FOR THE TREATMENT OF DIABETES<br/>[FR] DERIVES DE PYRROLE-2, 5-DIONE DESTINES AU TRAITEMENT DU DIABETE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2001074771A1

  公开（公告）日：2001-10-11

  A method for the treatment of conditions associated with a need for inhibition of GSK-3, which method comprises the administration of a pharmaceutically effective, non-toxic amount of a compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein R1 is a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring, which ring may be fused to a substituted or unsubstituted carbocyclic or heterocyclic aromatic or non-aromatic ring; R2 is a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring, which ring may be fused to a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring, with the proviso that R2 is not 3-indolyl or a fused-ring derivative of 3-indolyl; R3 is hydrogen, or R?1 and R3¿ together with the nitrogen atom to which they are attached form a fused substituted or unsubstituted heterocylic ring; to a human or non-human mammal in need thereof.

  一种用于治疗需要抑制GSK-3的病症的方法，该方法包括向需要治疗的人类或非人哺乳动物中投与一种公认为药用的衍生物或化合物(I)的有效、非毒性剂量，其中R1是取代或未取代的碳环或杂环芳香环，该环可能与取代或未取代的碳环或杂环芳香环或非芳香环融合；R2是取代或未取代的碳环或杂环芳香环，该环可能与取代或未取代的碳环或杂环芳香环融合，但R2不是3-吲哚基或3-吲哚基的融合环衍生物；R3是氢，或R1和R3与它们连接的氮原子一起形成融合的取代或未取代的杂环环。