2-(6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)ethyl-triphenylphosphanium;bromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)ethyl-triphenylphosphanium;bromide
• 化学式: C33H36BrO2P
• 分子量: 575.5
• InChiKey: RNFZLMJQMJDHEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.79
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR PRESERVING PLATELET FUNCTION
  申请人：BIOVEC TRANSFUSION, LLC

  公开号：US20150056604A1

  公开（公告）日：2015-02-26

  Compositions and methods for maintaining platelet functionality and extending the shelf-life of platelets are described. Platelet preservation compositions include a photosensitizer and a plurality of platelet preservation agents. A method for preserving platelets and extending their shelf-life includes irradiating a platelet mixture containing a photosensitizer under conditions sufficient to activate the photosensitizer and inactivate microbes in the platelet mixture to form a microbe-depleted platelet preparation. A plurality of platelet preservation agents are added to the microbe-depleted platelet preparation for extending the platelet shelf-life. Prior to transfusion, the photosensitizer and platelet preservation agents can be removed by diafiltration and/or the use of compound adsorption devices.

  本文描述了维持血小板功能和延长血小板货架寿命的组合物和方法。血小板保存组合物包括光敏剂和多种血小板保存剂。一种保存血小板并延长其货架寿命的方法包括在足以激活光敏剂并灭活血小板混合物中的微生物的条件下，照射含有光敏剂的血小板混合物，以形成去除微生物的血小板制备物。在延长血小板货架寿命之前，向去除微生物的血小板制备物中添加多种血小板保存剂。在输血之前，可以通过透析和/或使用化合物吸附装置去除光敏剂和血小板保存剂。
• Specific mtor inhibitors in the treatment of x-linked adrenoleukodystrophy
  申请人：Fundación de la Comunidad Valenciana Centro de Investigación Principe Felipe

  公开号：EP2997977A1

  公开（公告）日：2016-03-23

  The invention relates to novel uses of specific mTOR inhibitors as a medicament, in particular for the treatment of X-linked adrenoleukodystrophy (X-ALD). The invention also relates to a method for identifying a compound potentially useful for the treatment and/or prevention of X-ALD.

  本发明涉及特异性mTOR抑制剂作为药物的新用途，特别是用于治疗X-连锁肾上腺白质营养不良症（X-ALD）。本发明还涉及一种鉴定可能用于治疗和/或预防 X-ALD 的化合物的方法。
• METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND FOR THE TREATMENT OF ADRENOLEUKODYSTROPHY
  申请人：Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)

  公开号：EP3118621A1

  公开（公告）日：2017-01-18

  The present invention is directed to a diagnostic method for adrenoleukodystrophy in a subject based on the determination of the levels of different markers. The invention also provides a method for monitoring the progression of an adrenoleukodystrophy, a method for monitoring the effect of an adrenoleukodystrophy therapy and fingolimod, an analogue, metabolite or derivative thereof, or a pharmaceutically acceptable salt thereof, for use in the treatment and/or prevention of an adrenoleukodystrophy.

  本发明涉及一种基于不同标记物水平测定的受试者肾上腺脑白质营养不良症的诊断方法。本发明还提供了一种监测肾上腺白质营养不良症进展的方法、一种监测肾上腺白质营养不良症治疗效果的方法以及用于治疗和/或预防肾上腺白质营养不良症的芬戈莫德、其类似物、代谢物或衍生物或其药学上可接受的盐。
• Specific mTOR inhibitors in the treatment of X-linked adrenoleukodystrophy
  申请人：FUNDACIÓN DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE

  公开号：US10071063B2

  公开（公告）日：2018-09-11

  The invention relates to novel uses of specific mTOR inhibitors as a medicament, in particular for the treatment of X-linked adrenoleukodystrophy (X-ALD). The invention also relates to a method for identifying a compound potentially useful for the treatment and/or prevention of X-ALD.

  本发明涉及特异性mTOR抑制剂作为药物的新用途，特别是用于治疗X-连锁肾上腺白质营养不良症（X-ALD）。本发明还涉及一种鉴定可能用于治疗和/或预防 X-ALD 的化合物的方法。
• MITOCHONDRIALLY TARGETED ANTIOXIDANTS IN THE TREATMENT OF LIVER DISEASES AND EPITHELIAL CANCERS
  申请人：Oridis Biomed Forschungs- und Entwicklungs GmbH

  公开号：EP1765413A2

  公开（公告）日：2007-03-28