(R,R)-Dihydro Bupropion Hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R,R)-Dihydro Bupropion Hydrochloride
• 英文别名: (1R,2R)-2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-ol;hydrochloride
• 化学式: C13H21Cl2NO
• 分子量: 278.21
• InChiKey: YZHVQDVGTAELNB-KATIXKQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.57
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  32.3
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• Bupropion metabolites and methods of their synthesis and use
  申请人：SEPRACOR INC.

  公开号：US20020052341A1

  公开（公告）日：2002-05-02

  Methods and compositions are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, sexual dysfunction, affective disorders, cerebral function disorders, cigarette smoking, and incontinence. Methods of making optically pure bupropion metabolites are also disclosed.

  本文披露了利用伯泊隆代谢物治疗神经元单胺重摄取抑制所改善的疾病的方法和组合物。这些疾病包括但不限于性功能障碍、情感障碍、脑功能障碍、吸烟和失禁。本文还披露了制备光学纯伯泊隆代谢物的方法。
• Bupropion Metabolites and Methods of their Synthesis and Use
  申请人：SEPRACOR, INC.

  公开号：EP1602369A2

  公开（公告）日：2005-12-07

  Methods and compositions are disclosed which utilize metabolites of bupropion for trearing disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, sexual dysfunction, affective disorders, cerebral function disorders, cigarette smoking, and incontinence. Methods of making optically pure bupropion metabolites are also disclosed.

  本研究公开了利用安非他酮代谢物治疗因抑制神经元单胺再摄取而恶化的疾病的方法和组合物。这些疾病包括但不限于性功能障碍、情感障碍、脑功能障碍、吸烟和大小便失禁。还公开了制造光学纯安非他明代谢物的方法。