(1-Oxidopiperidin-1-ium-4-yl) 2-hydroxy-2,2-diphenylacetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1-Oxidopiperidin-1-ium-4-yl) 2-hydroxy-2,2-diphenylacetate
• 化学式: C19H21NO4
• 分子量: 327.4
• InChiKey: YXDDPFWNNDMSNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  68
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Deuterated n-substituted and alpha-substituted diphenylalkoxy acetic acid amino alkyl esters and medicaments containing these compounds
  申请人：——

  公开号：US20040242887A1

  公开（公告）日：2004-12-02

  The invention discloses deuterated N-substituted &agr;,&agr;-diphenyl &agr;-alkoxy acetic acid aminoalkyl esters as well as the physiologically tolerated salts thereof. Furthermore, the invention concerns the use of deuterated N-substituted &agr;,&agr;-diphenyl &agr;-alkoxy acetic acid aminoalkyl esters for the treatment of hypertonic functional states in the region of the urinary bladder as well as for the preparation of pharmaceutical drugs for the treatment of hypertonic functional states in the region of the urinary bladder. In addition, the invention discloses pharmaceutical formulations containing deuterated N-substituted &agr;,&agr;-diphenyl &agr;-alkoxy acetic acid aminoalkyl esters as well as the physiologically tolerated salts thereof for the treatment of hypertonic functional states in the region of the urinary bladder in addition to containing pharmaceutically tolerated adjuvants and/or additives.

  本发明公开了氘代 N-取代的&agr;,&agr;-二苯基&agr;-烷氧基乙酸氨基烷基酯及其生理耐受盐。此外，本发明还涉及氘代 N-取代的&agr;,&agr;-二苯基&agr;-烷氧基乙酸氨基烷基酯用于治疗膀胱区域的高渗功能状态，以及用于制备治疗膀胱区域高渗功能状态的药物。 此外，本发明还公开了含有氚代N-取代的&agr;,&agr;-二苯基&agr;-烷氧基乙酸氨基烷基酯及其生理上可耐受的盐的药物制剂，用于治疗膀胱区域的高渗功能状态，此外还含有药物上可耐受的佐剂和/或添加剂。