1,1'-(2,2-二甲基-1,3-丙二基)双[3,4-二氯-1H-吡咯-2,5-二酮 | 203115-63-3

• 物质功能分类: 医药中间体
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,1'-(2,2-二甲基-1,3-丙二基)双[3,4-二氯-1H-吡咯-2,5-二酮
• 英文名称: 3,4-Dichloro-1-[3-(3,4-dichloro-2,5-dioxopyrrol-1-yl)-2,2-dimethylpropyl]pyrrole-2,5-dione
• CAS: 203115-63-3
• 化学式: C₁₃H₁₀Cl₄N₂O₄
• 分子量: 400.0
• InChiKey: PCOXPBOKDABARQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• METHODS AND COMPOSITIONS FOR GENOMIC INTEGRATION
  申请人：Myeloid Therapeutics, Inc.

  公开号：EP4025686A2

  公开（公告）日：2022-07-13
• METHODS OF INHIBITING PROLIFERATIVE CELLS
  申请人：IDEAYA BIOSCIENCES, INC.

  公开号：US20210371855A1

  公开（公告）日：2021-12-02

  The present invention provides methods of negatively modulating the Werner protein (WRN) to inhibit proliferative cells characterized by high microsatellite instability (MSI-H), for example to treat proliferative diseases (such as cancer) characterized by high MSI (MSI-H). Further provided are compositions used in such methods.
• THERAPEUTIC TREATMENT OF MICROSATELLITE UNSTABLE CANCERS
  申请人：THE BROAD INSTITUTE, INC.

  公开号：US20220133693A1

  公开（公告）日：2022-05-05

  The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of microsatellite unstable cancers. In particular, the instant disclosure provides for identification of a cancer as exhibiting microsatellite instability (MSI) and/or impaired mismatch repair (MMR), and selection and/or administration of an inhibitor of the WRN helicase as a therapeutic agent for such a cancer and/or subject having or at risk of developing such a cancer.
• [EN] METHODS AND COMPOSITIONS FOR GENOMIC INTEGRATION<br/>[FR] MÉTHODES ET COMPOSITIONS D'INTÉGRATION GÉNOMIQUE
  申请人：[en]MYELOID THERAPEUTICS, INC.

  公开号：WO2021046243A2

  公开（公告）日：2021-03-11

  Methods and composition for modulating a target genome and stable integration of a transgene of interest into the genome of a cell are disclosed.