1-(2,6-Dichlorophenyl)-1-[6-(4-fluoro-2-methylphenyl)-5-(hydroxymethyl)pyridin-2-yl]urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(2,6-Dichlorophenyl)-1-[6-(4-fluoro-2-methylphenyl)-5-(hydroxymethyl)pyridin-2-yl]urea
• 化学式: C₂₀H₁₆Cl₂FN₃O₂
• 分子量: 420.3
• InChiKey: NQSHTDLBYYHYBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  79.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• HETEROCYCLIC INHIBITORS OF P38
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1077943B1

  公开（公告）日：2008-12-17
• Inhibitors of p38
  申请人：Salituro Francesco

  公开号：US20070060572A1

  公开（公告）日：2007-03-15

  The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
• INHIBITORS OF p38
  申请人：Salituro Francesco

  公开号：US20090075981A1

  公开（公告）日：2009-03-19

  The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
• US7423049B2
  申请人：——

  公开号：US7423049B2

  公开（公告）日：2008-09-09