1,1'-氧基二(3,4-二氯苯) | 56348-72-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,1'-氧基二(3,4-二氯苯)
• 英文名称: 3,3',4,4'-tetrachlorodiphenyl ether
• 英文别名: 3,3',4,4'-Tetrachlorobiphenyl ether；3,3',4,4'-tetrachlorodiphehyl ether；3,3',4,4'-tetrachlorodiphenylether；3,3',4,4'-tetrachlorophenyl ether；3,3',4,4'-PCDE；bis-(3,4-dichloro-phenyl) ether；1,2-dichloro-4-(3,4-dichlorophenoxy)benzene
• CAS: 56348-72-2
• 化学式: C₁₂H₆Cl₄O
• 分子量: 307.991
• InChiKey: DHLVZXZRIZBPKG-UHFFFAOYSA-N

物化性质

• 溶解度：
  可溶于DCM、DMSO、乙酸乙酯

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1'-氧基二(3,4-二氯苯) 在 三氯化铝 、 三氯化磷 作用下， 生成 2,3,7,8-Tetrachlorphenoxaphosphin-10-oxid
  参考文献：
  名称：

  Granoth,I., Israel Journal of Chemistry, 1974, vol. 12, p. 977 - 979

  摘要：

  DOI：
• 作为产物：
  描述：

  3,4-二氯苯酚 以51%的产率得到
  参考文献：
  名称：

  Nevalainen Taplo, Koistinen Jaana, Nurmela Pirjo, Environ. Sci. and Technol., 28 (1994) N 7, S 1341-1347

  摘要：

  DOI：

文献信息

• Synthesis, Structure Verification, and Chromatographic Relative Retention Times for Polychlorinated Diphenyl Ethers
  作者：Tapio. Nevalainen、Jaana. Koistinen、Pirjo. Nurmela

  DOI：10.1021/es00056a024

  日期：1994.7.1

  Fifty-four polychlorinated diphenyl ether (PCDEs) congeners were synthesized, and their structures were confirmed by mass spectrometry and proton magnetic resonance spectroscopy. The gas chromatographic relative retention times (RRT) for the PCDEs were determined relative to a reference standard, [C-13-3,3',4,4']-tetrachlorobiphenyl (PCB 77) on the fused silica capillary columns of SE-54 and OV-1701. The retention times for PCDEs increased with the increasing number of vicinal chlorines within a series of isomers. The chlorine substitution patterns of PCDEs were used to develop a method for predicting RRTs for congeners that were not synthesized.
• NORSTROEM A.; CHAUDHARY S. K.; ALBRO P. W.; MCKINNEY J. D., CHEMOSPHERE, 1979, 8, NO 6, 331-343
  作者：NORSTROEM A.、 CHAUDHARY S. K.、 ALBRO P. W.、 MCKINNEY J. D.

  DOI：——

  日期：——
• Nevalainen Taplo, Koistinen Jaana, Nurmela Pirjo, Environ. Sci. and Technol., 28 (1994) N 7, S 1341-1347
  作者：Nevalainen Taplo, Koistinen Jaana, Nurmela Pirjo

  DOI：——

  日期：——
• PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20200087399A1

  公开（公告）日：2020-03-19

  Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.
• Granoth,I., Israel Journal of Chemistry, 1974, vol. 12, p. 977 - 979
  作者：Granoth,I.

  DOI：——

  日期：——