4-[4-[3-[(2,4-Difluorophenyl)sulfonylamino]phenyl]-1,3-thiazol-2-yl]-5-methylthiophene-2-carboximidamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-[3-[(2,4-Difluorophenyl)sulfonylamino]phenyl]-1,3-thiazol-2-yl]-5-methylthiophene-2-carboximidamide
• 化学式: C₂₁H₁₆F₂N₄O₂S₃
• 分子量: 490.6
• InChiKey: FWGOMTWKLMVQJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  174
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR
  申请人：3-DIMENSIONAL PHARMACEUTICALS, INC.

  公开号：EP1152759A2

  公开（公告）日：2001-11-14
• US6492403B1
  申请人：——

  公开号：US6492403B1

  公开（公告）日：2002-12-10
• US6515002B2
  申请人：——

  公开号：US6515002B2

  公开（公告）日：2003-02-04
• [EN] METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR<br/>[FR] METHODES DE TRAITEMENT DE MALADIES ET PATHOLOGIES INDUITES PAR C1s, COMPOSES ET COMPOSITIONS PREPARES A CET EFFET
  申请人：ILLIG CARL R

  公开号：WO2000047194A2

  公开（公告）日：2000-08-17

  Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, like inflammation, sepsis, tissue damage, autoimmune disorders, adult respiratory distress syndrome, hemolytic anemia, myasthenia gravis, immune complex induced vasculitis, glomerulonephritis, arthritis, allergic neuritis, graves disease, insulin resistance, systemic lupus erythematosus, graft rejection, neurodegenerative diseases including Alzheimer's disease, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R?1, R2, R3, R4¿, X, Y and Z are defined in the specification.