5-[[3-[3-(1-Adamantyl)-5-fluoro-4-hydroxyphenyl]phenyl]methyl]-2-morpholin-4-yl-1,3-thiazol-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[[3-[3-(1-Adamantyl)-5-fluoro-4-hydroxyphenyl]phenyl]methyl]-2-morpholin-4-yl-1,3-thiazol-4-one
• 化学式: C₃₀H₃₃FN₂O₃S
• 分子量: 520.7
• InChiKey: PAGYFVBRLFNEEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  87.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 2-Substituted thiazolidinone and oxazolidinone derivatives for the inhibition of phosphatases and the treatment of cancer
  申请人：——

  公开号：US20040097566A1

  公开（公告）日：2004-05-20

  The present invention relates to certain substituted heterocycles, including 2-substituted thiazolidinone and 2-substituted oxazolidinone compounds. These compounds are useful in the treatment of diseases related to uncontrolled cellular proliferation, such as cancer or precancerous conditions. The compounds are also useful for modulating lipid and/or carbohydrate metabolism, and treating Type II diabetes, hyperglycemia or obesity, and for treating inflammatory diseases such as arthritis. Some disclosed embodiments of the invention relate to compounds having the structures indicated below, or a pharmaceutically acceptable salt thereof. 1

  本发明涉及某些取代杂环化合物，包括2-取代噻唑烷酮和2-取代噁唑烷酮化合物。这些化合物在治疗与细胞无法控制增殖相关的疾病，如癌症或癌前病变方面非常有用。这些化合物还可用于调节脂质和/或碳水化合物代谢，治疗II型糖尿病、高血糖或肥胖症，以及治疗炎症性疾病，如关节炎。本发明的某些实施例涉及具有下面所示结构的化合物或其药学上可接受的盐。1
• 2-SUBSTITUTED THIAZOLIDINONE AND OXAZOLIDINONE DERIVATIVES FOR THE INHIBITION OF PHOSPHATASES AND THE TREATMENT OF CANCER
  申请人：Incyte San Diego Incorporated

  公开号：EP1463718A1

  公开（公告）日：2004-10-06
• [EN] 2-SUBSTITUTED THIAZOLIDINONE AND OXAZOLIDINONE DERIVATIVES FOR THE INHIBITION OF PHOSPHATASES AND THE TREATMENT OF CANCER<br/>[FR] DERIVES THIAZOLIDINONE ET OXAZOLIDINONE 2-SUBSTITUES POUR L'INHIBITION DES PHOSPHATASES ET LE TRAITEMENT DU CANCER
  申请人：MAXIA PHARMACEUTICALS INC

  公开号：WO2003050098A1

  公开（公告）日：2003-06-19

  The present invention relates to certain substituted heterocycles, including 2-substituted thiazolidinone and 2-substituted oxazolidinone compounds. These compounds are useful in the treatment of diseases related to uncontrolled cellular proliferation, such as cancer or precancerous conditions. The compounds are also useful for modulating lipid and/or carbohydrate metabolism, and treating Type lI diabetes, hyperglycemia or obesity, and for treating inflammatory diseases such as arthritis. Some disclosed embodiments of the invention relate to compounds having the structures indicated below, or a pharmaceutically acceptable salt thereof, Formula (I) or (II).