2-[5-amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl]-N-[1-[[5-(α,α-dimethyl-3,4-methylenedioxybenzyl)-1,3,4-oxadiazole-2-yl]carbonyl]-2-methylpropyl]acetamide | 251958-31-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 2-[5-amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl]-N-[1-[[5-(α,α-dimethyl-3,4-methylenedioxybenzyl)-1,3,4-oxadiazole-2-yl]carbonyl]-2-methylpropyl]acetamide
• 英文别名: 2-(5-amino-6-oxo-2-phenylpyrimidin-1-yl)-N-[1-[5-[2-(1,3-benzodioxol-5-yl)propan-2-yl]-1,3,4-oxadiazol-2-yl]-3-methyl-1-oxobutan-2-yl]acetamide
• CAS: 251958-31-3
• 化学式: C₂₉H₃₀N₆O₆
• 分子量: 558.594
• InChiKey: LOUJAIBDWWRFJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  162
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Remedies for inflammatory bowel diseases
  申请人：——

  公开号：US20030212115A1

  公开（公告）日：2003-11-13

  Prophylactic and/or therapeutic drugs against ulcerative colitis, which include five-member heterocyclic compounds represented by the formula (I) or these nontoxic salts as active principle, 1 (wherein Z represents the group containing &agr;-aminocarbonyl group, R 1 represents (1) substituted alkyl, alkenyl or alkynyl groups, (2) OH, (3) amino, (4) alkylamino, (5) dialkylamino, etc., X and Y represent oxygen atom, sulfur atom or substituted nitrogen atom.)

  预防和/或治疗溃疡性结肠炎的药物，包括由式(I)表示的五元杂环化合物或这些无毒盐作为活性成分，其中Z代表含有α-氨基羰基的基团，R1代表(1)取代烷基、烯基或炔基基团，(2) OH，(3) 氨基，(4) 烷基氨基，(5) 二烷基氨基等，X和Y代表氧原子、硫原子或取代的氮原子。
• Airway mucus secretion inhibitors
  申请人：——

  公开号：US20030216324A1

  公开（公告）日：2003-11-20

  Prophylactic and/or therapeutic drugs against diseases with the augmentative airway mucus secretion, which include five-member heterocyclic compounds represented by the formula (I) or these nontoxic salts as active principle, 1 (wherein Z represents the group containing &agr;-aminocarbonyl group, R 1 represents (1) substituted alkyl, alkenyl or alkynyl groups, (2)OH, (3)amino, (4)alkylamino, (5)dialkylamino, etc., X and Y represent oxygen atom, sulfur atom or substituted nitrogen atom.)

  预防和/或治疗增多的气道粘液分泌疾病的药物，包括由式(I)所代表的五元杂环化合物或这些无毒盐作为活性原理，其中Z代表含有α-氨基羰基的基团，R1代表(1)取代烷基、烯基或炔基基团，(2) OH，(3) 氨基，(4) 烷基氨基，(5) 二烷基氨基等，X和Y代表氧原子、硫原子或取代的氮原子。
• REMEDIES FOR INFLAMMATORY BOWEL DISEASES
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1323420A1

  公开（公告）日：2003-07-02

  Prophylactic and/or therapeutic drugs against ulcerative colitis, which include five-member heterocyclic compounds represented by the formula (I) or these nontoxic salts as active principle, (wherein Z represents the group containing α-aminocarbonyl group, R1 represents (1) substituted alkyl, alkenyl or alkynyl groups, (2)OH, (3)amino, (4)alkylamino, (5)dialkylamino, etc., X and Y represent oxygen atom, sulfur atom or substituted nitrogen atom.)

  溃疡性结肠炎的预防和/或治疗药物，其活性成分包括由式(I)代表的五元杂环化合物或这些无毒盐、 (其中 Z 代表含有α-氨基羰基的基团，R1 代表(1)取代的烷基、烯基或炔基，(2)OH，(3)氨基，(4)烷基氨基，(5)二烷基氨基等，X 和 Y 代表氧原子、硫原子或取代的氮原子）。
• AIRWAY MUCUS SECRETION INHIBITORS
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1323419A1

  公开（公告）日：2003-07-02

  Prophylactic and/or therapeutic drugs against diseases with the augmentative airway mucus secretion, which include five-member heterocyclic compounds represented by the formula (I) or these nontoxic salts as active principle, (wherein Z represents the group containing α-aminocarbonyl group, R1 represents (1) substituted alkyl, alkenyl or alkynyl groups, (2)OH, (3)amino, (4)alkylamino, (5)dialkylamino, etc., X and Y represent oxygen atom, sulfur atom or substituted nitrogen atom.)

  预防和/或治疗气道粘液分泌增多性疾病的药物，其活性成分包括由式(I)代表的五元杂环化合物或这些无毒盐、 (其中 Z 代表含有α-氨基羰基的基团，R1 代表(1) 取代的烷基、烯基或炔基，(2)OH，(3)氨基，(4)烷基氨基，(5)二烷基氨基等，X 和 Y 代表氧原子、硫原子或取代的氮原子）。