[(1S,3S,5Z,7R,8E,11R,13E,15S,17R,21R,23R,25S)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-25-yl] 3-methylbutanoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: [(1S,3S,5Z,7R,8E,11R,13E,15S,17R,21R,23R,25S)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-25-yl] 3-methylbutanoate
• 化学式: C₄₂H₆₄O₁₅
• 分子量: 808.9
• InChiKey: ASKILCNAKQELBN-UOUKMDSOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  57
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  214
• 氢给体数：
  4
• 氢受体数：
  15

文献信息

• Bryostatins
  申请人：ARIZONA BOARD OF REGENTS

  公开号：EP0264173A2

  公开（公告）日：1988-04-20

  New and exceptionally potent antineoplastic agents denominated Bryostatin 9, Bryostatin 10, Bryostatin 11, Bryostatin 12 and Bryostatin 13 have been isolated from the marine animal Bugula neritina (Linneaeus) (Bryozoan phylum) and the structures identified. Meaningful antineoplastic activity is found for each.

  从海洋动物 Bugula neritina（Linneaeus）（毛霉菌门）中分离出了新型特效抗肿瘤物质，分别称为 Bryostatin 9、Bryostatin 10、Bryostatin 11、Bryostatin 12 和 Bryostatin 13，并确定了其结构。每种物质都具有重要的抗肿瘤活性。
• JPH07252146A
  申请人：——

  公开号：JPH07252146A

  公开（公告）日：1995-10-03
• JPH0892085A
  申请人：——

  公开号：JPH0892085A

  公开（公告）日：1996-04-09
• Methods and pharmaceutical compositions for healing wounds
  申请人：Tennenbaum Tamar

  公开号：US20060258562A1

  公开（公告）日：2006-11-16

  Methods and pharmaceutical compositions for inducing or accelerating a healing process of a damaged skin or skin wound, comprise modulating expression and/or activity of at least two PKC isoforms in skin cells colonizing the damaged skin or skin wound area.
• Biosynthesis of bryostatins by polyketide synthases (PKS)
  申请人：Targett M. Nancy

  公开号：US20070026488A1

  公开（公告）日：2007-02-01

  The present invention relates to the discovery, isolation and sequencing of novel polyketide synthase genes. These newly identified genes are involved in the biosynthesis of bryostatins. The genes are found to be expressed in all life stages of Bugula neritina, are associated with the bacterial symbiont Endobugula sertula and are believed to be part of a large polyketide gene cluster that is responsible for the production of bryostatins.