异苯并二氢吡喃-4-醇 | 20924-57-6

• 物质功能分类: 医药中间体 - 吡喃类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 异苯并二氢吡喃-4-醇
• 英文名称: Isochromanol-4
• 英文别名: isochroman-4-ol；3,4-dihydro-1H-isochromen-4-ol
• CAS: 20924-57-6
• 化学式: C₉H₁₀O₂
• 分子量: 150.177
• InChiKey: IXFIRBDJVKBOFO-UHFFFAOYSA-N

物化性质

• 熔点：
  68 °C
• 沸点：
  310.3±32.0 °C(Predicted)
• 密度：
  1.208±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335

反应信息

• 作为反应物：
  描述：

  异苯并二氢吡喃-4-醇 在 吡啶 、 氯化亚砜 作用下， 以 乙醚 为溶剂， 以99%的产率得到4-chloro-3,4-dihydro-1H-isochromene
  参考文献：
  名称：

  WO2006/64339

  摘要：

  公开号：

文献信息

• Methods of treatment of amyloidosis using bi-cyclic aspartyl protease inhibitors
  申请人：John Varghese

  公开号：US20050239832A1

  公开（公告）日：2005-10-27

  The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

  本发明涉及新型化合物和治疗与淀粉样变性相关的疾病、紊乱和状况的方法。淀粉样变性是指与A-beta蛋白异常沉积相关的一系列疾病、紊乱和状况的集合。
• 2-Amino- and 2-thio- substituted 1,3-diaminopropanes
  申请人：Hom Roy

  公开号：US20050267199A1

  公开（公告）日：2005-12-01

  Disclosed are compounds of the formula: where variables Q, Z, X, R 15 , R 2 , R 3 , and R c are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.

  本发明揭示了以下式子的化合物：其中变量Q、Z、X、R15、R2、R3和R4在此定义。本发明揭示的化合物是β-分泌酶酶的抑制剂，因此在治疗老年痴呆症和其他以哺乳动物体内A beta 肽沉积为特征的疾病中有用。
• Acetyl 2-hydroxy-1, 3-diaminoalkanes
  申请人：——

  公开号：US20040180939A1

  公开（公告）日：2004-09-16

  Disclosed are compounds of the formula: 1 where variables Z, X, R 15 , R 2 , R 3 , and R c are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.

  本发明揭示了公式1的化合物：其中变量Z、X、R15、R2、R3和Rc的定义如下。本发明所揭示的化合物是β-分泌酶酶的抑制剂，因此在治疗老年痴呆症和其他以A beta肽在哺乳动物中沉积为特征的疾病方面有用。
• Chromane Substituted Benzimidazole Derivatives as Acid Pump Antagonists
  申请人：Koike Hiroki

  公开号：US20080214519A1

  公开（公告）日：2008-09-04

  This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, B, X, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 , R 7 , R 8 and R 9 are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.

  本发明涉及式(I)的化合物或其药学上可接受的盐，其中：A、B、X、R1、R2、R3、R4、R5和R6、R7、R8和R9分别如本文所述或其药学上可接受的盐，以及包含这种化合物的组合物以及在治疗由酸泵拮抗活性介导的疾病，如但不限于胃肠疾病、胃食管疾病、胃食管反流病（GERD）、消化性溃疡、胃溃疡、十二指肠溃疡、NSAID诱导性溃疡、胃炎、幽门螺杆菌感染、消化不良、功能性消化不良、佐林格-埃里森综合症、非侵蚀性反流性疾病（NERD）、内脏疼痛、心口灼热、恶心、食管炎、吞咽困难、多口水、气道障碍或哮喘等疾病中使用这种化合物的用途。
• Chromane Derivatives Useful As Acid Pump Antagonists
  申请人：Jinno Madoka

  公开号：US20090291977A1

  公开（公告）日：2009-11-26

  This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R′, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 A and B are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method of treatment and the use, comprising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori , dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-crosive reflux disease (NERD), visceral pain, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.

  本发明涉及式（I）的化合物或其药学上可接受的盐，其中：R′、R2、R3、R4、R5、R6、R7、R8A和B分别如本文所述或其药学上可接受的盐，以及含有这种化合物的组合物、治疗方法和使用，包括用于治疗酸泵拮抗活性介导的疾病，如但不限于胃肠疾病、胃食管疾病、胃食管反流病（GERD）、消化性溃疡、胃溃疡、十二指肠溃疡、NSAID所致溃疡、胃炎、幽门螺杆菌感染、消化不良、功能性消化不良、佐林格-埃里森综合征、非腐蚀性反流病（NERD）、内脏疼痛、心口灼热、恶心、食管炎、吞咽困难、多唾液、呼吸道疾病或哮喘。