5-[(4-isopropylphenyl)sufonyl]-imidazo[1',2':1,6]pyrido[2,3-b]pyrazin-6-amine | 393802-25-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶吡嗪类
• 英文名称: 5-[(4-isopropylphenyl)sufonyl]-imidazo[1',2':1,6]pyrido[2,3-b]pyrazin-6-amine
• 英文别名: 8-(4-Propan-2-ylphenyl)sulfonyl-2,5,10,13-tetrazatricyclo[7.4.0.02,6]trideca-1(13),3,5,7,9,11-hexaen-7-amine
• CAS: 393802-25-0
• 化学式: C₁₈H₁₇N₅O₂S
• 分子量: 367.431
• InChiKey: OHKOLXCHRUIWSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 5-Arylsulfonyl-imidazo[1',2':1,6]pyrido[2,3-b]pyrazine-6-amines and related compounds
  申请人：——

  公开号：US20030203911A1

  公开（公告）日：2003-10-30

  A compound of the formula 1 wherein a, X, R 1 , R 2 , R 3 and R 4 are as defined above, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, inflammatory and central nervous system disorders such as asthma, chronic obstructive pulmonary disease, adult respiratory diseases syndrome, shock, fibrosis, pulmonary hypersensitivity, allergic rhinitis, atopic dermatitis, psoriasis, weight control, rheumatoid arthritis, cachexia, crohn's disease, ulcerative colitis, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS.

  式1的化合物，其中a，X，R1，R2，R3和R4如上所定义，可用于治疗呼吸系统，过敏，风湿性，体重调节，炎症和中枢神经系统疾病，如哮喘，慢性阻塞性肺疾病，成人呼吸系统疾病综合征，休克，纤维化，肺过敏，过敏性鼻炎，特应性皮炎，银屑病，体重控制，风湿性关节炎，恶病质，克罗恩病，溃疡性结肠炎，关节炎和其他炎症性疾病，抑郁症，多发性梗塞性痴呆和艾滋病。
• 5-arylsulfonyl-imidazo[1'2':1,6]pyrido[2,3-b]pyrazine-6-amines and related compounds
  申请人：——

  公开号：US20020013467A1

  公开（公告）日：2002-01-31

  A compound of the formula 1 wherein a, X, R 1 , R 2 , R 3 and R 4 are as defined above, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, inflammatory and central nervous system disorders such as asthma, chronic obstructive pulmonary disease, adult respiratory diseases syndrome, shock, fibrosis, pulmonary hypersensitivity, allergic rhinitis, atopic dermatitis, psoriasis, weight control, rheumatoid arthritis, cachexia, crohn's disease, ulcerative colitis, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS.

  一种化合物的公式为1，其中a，X，R1，R2，R3和R4如上所定义，可用于治疗呼吸系统、过敏、类风湿、体重调节、炎症和中枢神经系统紊乱，如哮喘、慢性阻塞性肺疾病、成人呼吸系统疾病综合征、休克、纤维化、肺过敏、过敏性鼻炎、特应性皮炎、银屑病、体重控制、类风湿性关节炎、消瘦、克罗恩病、溃疡性结肠炎、关节炎和其他炎症性疾病、抑郁症、多发性脑梗死和艾滋病。
• 5-arylsulfonyl-imidazo[1',2':1,6]pyrido[2,3-b]pyrazine-6-amines and related compounds
  申请人：——

  公开号：US20020147340A1

  公开（公告）日：2002-10-10

  A compound of the formula 1 wherein a, X, R 1 , R 2 , R 3 and R 4 are as defined above, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, inflammatory and central nervous system disorders such as asthma, chronic obstructive pulmonary disease, adult respiratory diseases syndrome, shock, fibrosis, pulmonary hypersensitivity, allergic rhinitis, atopic dermatitis, psoriasis, weight control, rheumatoid arthritis, cachexia, crohn's disease, ulcerative colitis, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS.

  化合物的公式1，其中a、X、R1、R2、R3和R4如上所定义，可用于治疗呼吸系统、过敏、风湿性、体重调节、炎症和中枢神经系统疾病，如哮喘、慢性阻塞性肺疾病、成人呼吸系统疾病综合征、休克、纤维化、肺过敏、过敏性鼻炎、特应性皮炎、银屑病、体重控制、风湿性关节炎、消瘦、克罗恩病、溃疡性结肠炎、关节炎和其他炎症性疾病、抑郁症、多发性梗塞性痴呆和艾滋病。
• US6555538B2
  申请人：——

  公开号：US6555538B2

  公开（公告）日：2003-04-29