2-[4-(4-Carbamimidoylphenyl)phenyl]imidazo[1,2-a]pyridine-6-carboximidamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-(4-Carbamimidoylphenyl)phenyl]imidazo[1,2-a]pyridine-6-carboximidamide
• 化学式: C₂₁H₁₈N₆
• 分子量: 354.4
• InChiKey: OTQBRWYINPWMAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  117
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8,-tetrahydro-imidazo[1,2,-a]pyridines as antiprotozoal agents
  申请人：Boykin W. David

  公开号：US20050282853A1

  公开（公告）日：2005-12-22

  A method for treating a microbial infection, including an infection from a protozoan pathogen, such as Trypanosoma brucei rhodesiense and Plasmodium falciparum , in a subject in need thereof by administering to the subject an effective amount of a dicationic imidazopyridine compound or a dicationic tetrahydro-imidazopyridine compound. Processes for synthesizing dicationic imidazopyridines and dicationic tetrahydro-imidazopyridines and the novel dicationic imidazopyridine and dicationic tetrahydro-imidazopyridine compounds themselves.

  一种治疗微生物感染的方法，包括治疗来自原虫病原体（如Trypanosoma brucei rhodesiense和Plasmodium falciparum）的感染，通过向需要的对象施用有效量的二阳离子咪唑吡啶化合物或二阳离子四氢咪唑吡啶化合物。合成二阳离子咪唑吡啶和二阳离子四氢咪唑吡啶的方法，以及新型的二阳离子咪唑吡啶和二阳离子四氢咪唑吡啶化合物本身。
• NOVEL DICATIONIC IMIDAZO 1,2-a PYRIDINES AND 5,6,7,8-TE TRAHYDRO-IMIDAZO 1,2a PYRIDINES AS ANTIPROTOZOAL AGENTS
  申请人：THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：EP1745045A2

  公开（公告）日：2007-01-24
• US7432278B2
  申请人：——

  公开号：US7432278B2

  公开（公告）日：2008-10-07
• [EN] NOVEL DICATIONIC IMIDAZO[1,2-a]PYRIDINES AND 5,6,7,8-TETRAHYDRO-IMIDAZO[1,2a]PYRIDINES AS ANTIPROTOZOAL AGENTS<br/>[FR] NOUVELLES C IMIDAZO[1,2-A]PYRIDINES DICATIONIQUE ET NOUVELLES 5,6,7,8-TETRAHYDRO-IMIDAZO[1,2A]PYRIDINES UTILISEE S COMME AGENTS ANTIPROTOZOAIRES
  申请人：UNIV NORTH CAROLINA

  公开号：WO2005086808A2

  公开（公告）日：2005-09-22

  A method for treating a microbial infection, including an infection from a protozoan pathogen, such as Trypanosoma brucei rhodesiense and Plasmodium falciparum, in a subject in need thereof by administering to the subject an effective amount of a dicationic imidazopyridine compound or a dicationic tetrahydro-imidazopyridine compound. Processes for synthesizing dicationic imidazopyridines and dicationic tetrahydro-imidazopyridines and the novel dicationic imidazopyridine and dicationic tetrahydro-imidazopyridine compounds themselves.