N,N-diethyl-4-[piperazin-1-yl-[3-(thiophen-3-ylmethylamino)phenyl]methyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diethyl-4-[piperazin-1-yl-[3-(thiophen-3-ylmethylamino)phenyl]methyl]benzamide
• 化学式: C₂₇H₃₄N₄OS
• 分子量: 462.7
• InChiKey: TUHXQAJMJAGUNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  75.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] 4(PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN OR GASTROINTESTINAL DISORDERS<br/>[FR] DERIVES DE 4(PHENYL-PIPERAZINYL-METHYL) BENZAMIDE ET LEUR UTILISATION POUR LE TRAITEMENT DE DOULEUR OU DE TROUBLES GASTRO-INTESTINAUX
  申请人：ASTRAZENECA AB

  公开号：WO2004041801A1

  公开（公告）日：2004-05-21

  Compounds of general formula:[Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

  通式化合物：[化学式应在此处插入。请参阅纸质副本]其中R1、R2和R3如规范中定义，以及其盐、对映体和包括该化合物的药物组合物已经制备。它们在治疗中很有用，特别是在疼痛管理中。
• 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders
  申请人：Brown William

  公开号：US20060142296A1

  公开（公告）日：2006-06-29

  Compounds of general formula:[Chemical formula should be inserted here. Please see paper copy] wherein R 1 , R 2 , and R 3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

  通式为：[此处应插入化学式。 请参见纸质副本]的化合物，其中 R 1 , R 2 和 R 3 以及盐类、其对映体和包括这些化合物的药物组合物。它们可用于治疗，尤其是疼痛治疗。
• 4(PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN OR GASTROINTESTINAL DISORDERS
  申请人：AstraZeneca AB

  公开号：EP1562923A1

  公开（公告）日：2005-08-17
• US7241764B2
  申请人：——

  公开号：US7241764B2

  公开（公告）日：2007-07-10