3-(4-{5-chloro-2-oxo-3-[4-(3-o-tolyl-ureido)phenyl]-2H-pyridin-1-ylmethyl}-phenyl)propionic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(4-{5-chloro-2-oxo-3-[4-(3-o-tolyl-ureido)phenyl]-2H-pyridin-1-ylmethyl}-phenyl)propionic acid
• 英文别名: 3-[4-[[5-Chloro-3-[4-[(2-methylphenyl)carbamoylamino]phenyl]-2-oxopyridin-1-yl]methyl]phenyl]propanoic acid
• 化学式: C₂₉H₂₆ClN₃O₄
• 分子量: 515.996
• InChiKey: VFKFYCHVNKSMOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  98.7
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Novel compounds
  申请人：Witherington Jason

  公开号：US20050288337A1

  公开（公告）日：2005-12-29

  The present invention relates to novel pyridone derivatives capable of inhibiting α 4 integrin mediated cell adhesion, processes for their preparation, compositions comprising them and their use in the treatment of diseases capable of being modulated by the inhibition of cell adhesion.

  本发明涉及一种新型吡啶酮衍生物，能够抑制α4整合素介导的细胞黏附，其制备方法、包含它们的组合物以及它们在治疗能够通过抑制细胞黏附来调节的疾病中的应用。
• PROCESS FOR PREPARING QUINOLIN ANTIBIOTIC INTERMEDIATES
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1539696A2

  公开（公告）日：2005-06-15
• US7410984B2
  申请人：——

  公开号：US7410984B2

  公开（公告）日：2008-08-12
• [EN] PROCESS FOR PREPARING QUINOLIN ANTIBIOTIC INTERMEDIATES<br/>[FR] NOUVEAUX COMPOSES
  申请人：TANABE SEIYAKU CO

  公开号：WO2004014859A2

  公开（公告）日：2004-02-19

  The present invention relates to novel pyridone derivatives capable of inhibiting a4 integrin medicated cell adhesion, processes for their preparation, compositions comprising them and their use in the treatment of diseases capable of being modulated by the inhibition of cell adhesion.