2-[2-(4-acetyl-1-piperazinyl)-1-hydroxyethyl]-4-(trifluoromethyl)-N-[1-[3-(trifluoromethyl)phenyl]ethyl]-5-thiazolecarboxamide | 724465-28-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-(4-acetyl-1-piperazinyl)-1-hydroxyethyl]-4-(trifluoromethyl)-N-[1-[3-(trifluoromethyl)phenyl]ethyl]-5-thiazolecarboxamide
• 英文别名: 2-[2-(4-acetylpiperazin-1-yl)-1-hydroxyethyl]-4-(trifluoromethyl)-N-[1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-thiazole-5-carboxamide
• CAS: 724465-28-5
• 化学式: C₂₂H₂₄F₆N₄O₃S
• 分子量: 538.514
• InChiKey: RDWFIVYCHAVFLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• Aminoalkyl thiazole derivatives as KCNQ modulators
  申请人：——

  公开号：US20040138268A1

  公开（公告）日：2004-07-15

  Novel aminoalkylthiazole derivatives of Formula I are described which are openers of KCNQ potassium channels and are useful in the treatment of disorders responsive to the opening of the KCNQ potassium channels, including pain and migraine. 1

  描述了一种公式I的新型氨基烷基噻唑衍生物，它们是KCNQ钾通道的开放剂，并可用于治疗对KCNQ钾通道开放有反应的疾病，包括疼痛和偏头痛。
• US6933308B2
  申请人：——

  公开号：US6933308B2

  公开（公告）日：2005-08-23
• [EN] AMINOALKYL THIAZOLE DERIVATIVES AS KCNQ MODULATORS<br/>[FR] DERIVES D'AMINOALKYLTHIAZOLE UTILISES EN TANT QUE MODULATEURS DES KCNQ
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2004060880A1

  公开（公告）日：2004-07-22

  Novel aminoalkylthiazole derivatives of Formula I are described which are openersof KCNQ potassium channels and are useful in the treatment of disorders responsiveto the opening of the KCNQ potassium channels, including pain and migraine. (I)