(2S,3S,4R)-2-(dimethoxymethyl)-2-methyl-4-[N-[(2-methyltetrazol-5-yl)methyl]-4-(trifluoromethyl)anilino]-6-nitro-3,4-dihydrochromen-3-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,3S,4R)-2-(dimethoxymethyl)-2-methyl-4-[N-[(2-methyltetrazol-5-yl)methyl]-4-(trifluoromethyl)anilino]-6-nitro-3,4-dihydrochromen-3-ol
• 化学式: C23H25F3N6O6
• 分子量: 538.5
• InChiKey: YDIWNBIOXVXABF-URVUXULASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  141
• 氢给体数：
  1
• 氢受体数：
  13

文献信息

• Benzopyran derivatives substituted with secondary amines including tetrazole, method for the preparation thereof and pharmaceutical compositions containing them
  申请人：Lim Hong

  公开号：US20060035948A1

  公开（公告）日：2006-02-16

  The present invention relates to benzopyran derivatives substituted with secondary amines including tetrazole, method for preparing thereof and pharmaceutical compositions containing them. The compounds of the present invention can be used for protecting neuronal cells and brain damage; antioxidation; inhibiting NO generation; protecting heart; suppressing angiogenesis; protecting preserving organs such as kidney, heart and tissue, and protecting organs in major cardiovascular surgery.

  本发明涉及用二级胺包括四唑取代的苯并吡喃衍生物，其制备方法以及含有它们的制药组合物。本发明的化合物可用于保护神经细胞和脑损伤；抗氧化；抑制NO生成；保护心脏；抑制血管生成；保护肾脏、心脏和组织等器官，并保护心血管手术中的器官。
• BENZOPYRAN DERIVATIVES SUBSTITUTED WITH SECONDARY AMINES INCLUDING TETRAZOLE, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Dongbu Hitek Co., Ltd.

  公开号：EP1499610B1

  公开（公告）日：2009-01-21
• US7414068B2
  申请人：——

  公开号：US7414068B2

  公开（公告）日：2008-08-19