Poly(oxy-1,2-ethanediyl), alpha-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]-omega-hydroxy- | 155919-13-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Poly(oxy-1,2-ethanediyl), alpha-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]-omega-hydroxy-
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 2-hydroxyethyl carbonate
• CAS: 155919-13-4
• 化学式: C₇H₉NO₆
• 分子量: 203.15
• InChiKey: ZHYROWSBSYXOGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  93.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] POLYMERIC CONJUGATES OF ADENINE NUCLEOSIDE ANALOGS<br/>[FR] CONJUGUÉS POLYMÈRES D'ANALOGUES D'ADÉNINE NUCLÉOSIDES
  申请人：ENZON PHARMACEUTICALS INC

  公开号：WO2011130599A1

  公开（公告）日：2011-10-20

  The present invention relates to polymeric conjugates of adenine nucleoside analogs. In particular, the invention relates to multi-arm polyethylene glycol conjugates of adenine nucleoside analogs and use thereof. The present invention, more specifically, provides polymeric conjugates of toyocamycin and its derivatives. Furthermore, the present invention provides a method for preparing the polymeric conjugates of adenine nucleoside analogs and a method of using the same for for treating a cancer, inhibiting the growth or proliferation of cancer cells, treating a viral infection, treating a disease or condition associated with abnormal expression of VEGF. Most polymeric conjugates of toyocamycin was stable in PBS but released toyocamycin in vivo to provided inhibition of cancer cell growth.

  本发明涉及腺嘌呤核苷类似物的聚合物共轭物。具体而言，本发明涉及腺嘌呤核苷类似物的多臂聚乙二醇共轭物及其使用。更具体地说，本发明提供了豆杆菌素及其衍生物的聚合物共轭物。此外，本发明还提供了制备腺嘌呤核苷类似物的聚合物共轭物的方法，以及使用该方法治疗癌症、抑制癌细胞的生长或增殖、治疗病毒感染、治疗与VEGF异常表达相关的疾病或病况的方法。大多数豆杆菌素的聚合物共轭物在PBS中稳定，但在体内释放豆杆菌素，从而提供了抑制癌细胞生长的作用。
• Bifunctional energy-reversible acyl-compositions
  申请人：——

  公开号：US20020187993A1

  公开（公告）日：2002-12-12

  Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include: 1

  本发明公开了可逆能量酰基结合物、中间体和相关组合物。在优选方面，这些组合物的示例包括：1
• Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
  申请人：Mountain View Pharmaceuticals, Inc.

  公开号：US20040062746A1

  公开（公告）日：2004-04-01

  Methods are provided for the preparation of conjugates of a variety of bioactive components, especially proteins, with water-soluble polymers (e.g., poly(ethylene glycol) and derivatives thereof), which conjugates have reduced antigenicity and immunogenicity compared to similar conjugates prepared using poly(ethylene glycol) containing a methoxyl or another alkoxyl group. The invention also provides conjugates prepared by such methods, compositions comprising such conjugates, kits containing such conjugates or compositions and methods of use of the conjugates and compositions in diagnostic and therapeutic protocols.

  提供了一种制备各种生物活性成分（尤其是蛋白质）与水溶性聚合物（例如聚乙二醇及其衍生物）结合物的方法，这些结合物与使用含有甲氧基或其他烷氧基的聚乙二醇制备的类似结合物相比，具有较低的抗原性和免疫原性。本发明还提供了通过这种方法制备的结合物，包含这种结合物的组合物，包含这种结合物或组合物的工具箱以及在诊断和治疗方案中使用这种结合物和组合物的方法。
• BIFUNCTIONAL ENERGY-REVERSIBLE ACYL-COMPOSITIONS
  申请人：Gilbert W. Carl

  公开号：US20070167644A1

  公开（公告）日：2007-07-19

  Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:

  本发明揭示了可逆能量酰基结合物、中间体和相关组成物。在优选方面，这样的组成物的例子包括：
• POLYMERIC CONJUGATES OF ADENINE NUCLEOSIDE ANALOGS
  申请人：Zhao Hong

  公开号：US20130018010A1

  公开（公告）日：2013-01-17

  The present invention relates to polymeric conjugates of adenine nucleoside analogs. In particular, the invention relates to multi-arm polyethylene glycol conjugates of adenine nucleoside analogs and use thereof. The present invention, more specifically, provides polymeric conjugates of toyocamycin and its derivatives. Furthermore, the present invention provides a method for preparing the polymeric conjugates of adenine nucleoside analogs and a method of using the same for treating a cancer, inhibiting the growth or proliferation of cancer cells, treating a viral infection, treating a disease or condition associated with abnormal expression of VEGF. Most polymeric conjugates of toyocamycin was stable in PBS but released toyocamycin in vivo to provided inhibition of cancer cell growth.

  本发明涉及腺嘌呤核苷类似物的聚合物共轭物。具体而言，本发明涉及腺嘌呤核苷类似物的多臂聚乙二醇共轭物及其使用。更具体地说，本发明提供了豆杆霉素及其衍生物的聚合物共轭物。此外，本发明提供了一种制备腺嘌呤核苷类似物的聚合物共轭物的方法以及使用该方法治疗癌症、抑制癌细胞生长或增殖、治疗病毒感染、治疗与VEGF异常表达相关的疾病或病况的方法。大多数豆杆霉素的聚合物共轭物在PBS中稳定，但在体内释放豆杆霉素以提供抑制癌细胞生长的作用。