1-(2,3,3a,4,5,6,7,7a-octahydro-1H-indole-2-carbonyl)azetidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 1-(2,3,3a,4,5,6,7,7a-octahydro-1H-indole-2-carbonyl)azetidin-2-one
• 化学式: C₁₂H₁₈N₂O₂
• 分子量: 222.28
• InChiKey: UBHDMXWRIMZGDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] SUBSTITUTED AZETIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV<br/>[FR] COMPOSES D'AZETIDINE SUBSTITUES SERVANT D'INHIBITEURS DE DIPEPTIDYL PEPTIDASE IV
  申请人：GUILFORD PHARM INC

  公开号：WO2004071454A2

  公开（公告）日：2004-08-26

  Novel azetidine-derived inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of such inhibitors, and novel methods of treating medical conditions are provided. The novel DPP IV inhibitors described herein feature an azetidine ring substituted with one or more groups selected from fluoro-, di-fluoro, oxo-, cyano, alkoxy, and alkyl, and are useful in the treatment of neurological disorders, mental illness, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other medical conditions as can be treated with inhibitors of DPP IV.