N-(1-azabicyclo[3.2.2]nonan-3-yl)-4-methylsulfanylpyrazole-1-carboxamide

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: N-(1-azabicyclo[3.2.2]nonan-3-yl)-4-methylsulfanylpyrazole-1-carboxamide
• 化学式: C₁₃H₂₀N₄OS
• 分子量: 280.39
• InChiKey: AYHYRHFHEAIWFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  75.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] 1H-PYRAZOLE AND 1H-PYRROLE-AZABICYCLIC COMPOUNDS WITH ALFA-7 NACHR ACTIVITY<br/>[FR] COMPOSES AZABICYCLIQUE DE 1H-PYRAZOLE ET 1H-PYRROLE SERVANT A EFFECTUER UN TRAITEMENT THERAPEUTIQUE
  申请人：UPJOHN CO

  公开号：WO2004013137A1

  公开（公告）日：2004-02-12

  The invention provides compounds of Formula (I), wherein Azabicyclo is Formula (I, II, III, IV, V, VI, VII); W is Formula (m); where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat a disease or condition in which α7 is known to be involved.

  这项发明提供了Formula (I)的化合物，其中Azabicyclo是Formula (I, II, III, IV, V, VI, VII); W是Formula (m); 其中变量的定义如本文所述。这些化合物可以是药用盐或组合物的形式，可以是纯对映体形式或混合物，对于治疗已知涉及α7的疾病或症状的药物具有用处。
• 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease
  申请人：——

  公开号：US20040087616A1

  公开（公告）日：2004-05-06

  The invention provides compounds of Formula I: 1 wherein Azabicyclo is 2 where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat a disease or condition in which &agr;7 is known to be involved.

  本发明提供了I式化合物：1其中Azabicyclo为2其中变量的定义如下所述。这些化合物可以是药物盐或组合物的形式，可以是纯对映体形式或混合物，可用于制备药物以治疗已知涉及α7的疾病或病症。
• 1H-pyrazole and 1h-pyrole-azabicyclic compounds for the treatment of disease
  申请人：Piotrowski W. David

  公开号：US20060116395A1

  公开（公告）日：2006-06-01

  The invention provides compounds of Formula I: wherein Azabicyclo is W is where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat a disease or condition in which α7 is known to be involved.

  本发明提供了I式化合物：其中Azabicyclo是W是其中变量的定义在此处讨论。这些化合物可以是药物盐或组合物的形式，可以是纯对映体形式或混合物，可用于制药以治疗已知α7参与的疾病或状况。
• 1H-PYRAZOLE AND 1H-PYRROLE-AZABICYCLIC COMPOUNDS WITH ALFA-7 NACHR ACTIVITY
  申请人：Pharmacia & Upjohn Company LLC

  公开号：EP1542999A1

  公开（公告）日：2005-06-22
• US7176198B2
  申请人：——

  公开号：US7176198B2

  公开（公告）日：2007-02-13