1-[3-(2,2-difluoro-benzo[1,3]dioxol-5-yloxy)propyloxy]-5-isopropyl biguanide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 1-[3-(2,2-difluoro-benzo[1,3]dioxol-5-yloxy)propyloxy]-5-isopropyl biguanide
• 英文别名: 1-[Amino-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)oxy]propoxyamino]methylidene]-2-propan-2-ylguanidine；1-[amino-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)oxy]propoxyamino]methylidene]-2-propan-2-ylguanidine
• 化学式: C₁₅H₂₁F₂N₅O₄
• 分子量: 373.36
• InChiKey: HTMQJEBJYXRNON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Biguanide and dihydrotriazine derivatives
  申请人：——

  公开号：US20040116428A1

  公开（公告）日：2004-06-17

  Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.

  本文披露了biguanide和二氢三嗪衍生物，最好是从羟胺衍生的取代不对称亚胺二碳酰胺二酰胺，以及含有biguanide和二氢三嗪衍生物的组合物。此外，本文还披露了使用biguanide和二氢三嗪衍生物的方法，包括作为抗微生物剂的方法，以及使用二氢三嗪衍生物进行生物测定的方法。还披露了制备biguanide和二氢三嗪衍生物的方法。
• [EN] BIGUANIDE AND DIHYDROTRIAZINE DERIVATIVES<br/>[FR] DERIVES DE BIGUANIDE DE D'HYDROTRIAZINE
  申请人：JACOBUS PHARMACEUTICAL COMPANY

  公开号：WO2004048320A1

  公开（公告）日：2004-06-10

  Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.

  本文披露了biguanide和dihydrotriazine衍生物，其中首选的是从羟胺衍生的取代不对称imidodicarbonimidic二酰胺，以及含有biguanide和dihydrotriazine衍生物的组合物。此外，本文还披露了使用biguanide和dihydrotriazine衍生物的方法，包括作为抗微生物剂的方法，以及使用dihydrotriazine衍生物进行生物测定的方法。本文还披露了制备biguanide和dihydrotriazine衍生物的方法。
• BIGUANIDE AND DIHYDROTRIAZINE DERIVATIVES
  申请人：Jacobus David P.

  公开号：US20080176852A1

  公开（公告）日：2008-07-24

  Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide and dihydrotriazine derivatives, inter alia, as antimicrobial agents and methods of using the dihydrotriazine derivatives in biological assays are disclosed. Methods of making the biguanide and dihydrotriazine derivatives are also disclosed.

  本发明公开了一种大双胍和二氢三嗪衍生物，其中优选的是来自羟胺的取代不对称亚氨基碳酰亚胺二酰胺，以及含有大双胍和二氢三嗪衍生物的组合物。此外，还公开了使用大双胍和二氢三嗪衍生物的方法，包括作为抗微生物剂的方法以及使用二氢三嗪衍生物进行生物测定的方法。还公开了制备大双胍和二氢三嗪衍生物的方法。
• BIGUANIDE DERIVATIVES
  申请人：JACOBUS PHARMACEUTICAL CO. INC.

  公开号：EP1565430B1

  公开（公告）日：2010-02-17
• US7256218B2
  申请人：——

  公开号：US7256218B2

  公开（公告）日：2007-08-14