1,2,3,4-四氢-1-(碘甲基)-萘 | 117408-87-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: 1,2,3,4-四氢-1-(碘甲基)-萘
• 英文名称: 1-(Iodomethyl)-1,2,3,4-tetrahydronaphthalene
• CAS: 117408-87-4
• 化学式: C₁₁H₁₃I
• 分子量: 272.129
• InChiKey: WQVYYDXVVMSGFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,2,3,4-四氢-1-(碘甲基)-萘 在 sodium hydroxide 、 四(三苯基膦)钯 、 铜 、 锌 作用下， 以 乙醇 、 水 为溶剂， 反应 76.0h， 生成
  参考文献：
  名称：

  2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution

  摘要：

  In this paper, we describe the synthesis of a series of a-substituted analogues of the potent and selective group II metabotropic glutamate receptor (mGluR) agonist (1S,1'S,2'S)-carboxy-cyclopropylglycine (2, L-CCG 1). Incorporation of a substituent on the amino acid carbon converted the agonist 2 into antagonist. Ail of the compounds were prepared and tested as a series of four isomers, i.e., two racemic diastereomers. We explored alkyl substitution, both normal and terminally branched; phenylalkyl and diphenylalkyl substitution; and a variety of aromatic and carbocyclic surrogates for phenyl. Affinity for group II mGluRs was measured using [H-3]glutamic acid (Glu) binding in rat forebrain membranes. Antagonist activity was confirmed for these compounds by measuring their ability to antagonize (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibition of forskolin-stimulated cyclic-AMP in RGT cells transfected with human mGluR2 and mGluR3. We found that while alkyl substitution provided no increase in affinity relative to 2, phenylethyl and diphenylethyl substitution, as in 105 and 109, respectively, were quite beneficial, The affinity of 109 was further enhanced when the two aromatic rings were joined by an oxygen or sulfur atom to form the tricyclic xanthylmethyl and thioxanthylmethyl amino acids 113 and 114, respectively. Amino acid 113, with an IC50 of 0.10 mu M in the [H-3]Glu binding assay, was 52-fold more patent than 2, whose IC50 was 0.47 mu M.

  DOI：

  10.1021/jm970497w
• 作为产物：
  描述：

  5-苯基-1-戊烯 在 tetrafluoroboric acid 、 bis(pyridine)iodonium tetrafluoroborate 作用下， 以92%的产率得到1,2,3,4-四氢-1-(碘甲基)-萘
  参考文献：
  名称：

  Barluenga, Jose; Gonzalez, Jose M.; Campos, Pedro J., Angewandte Chemie, 1988, vol. 100, # 11, p. 1604 - 1605

  摘要：

  DOI：

文献信息

• Transparent polymer film and electronic device including the same
  申请人：SAMSUNG ELECTRONICS CO., LTD.

  公开号：US11130320B2

  公开（公告）日：2021-09-28

  A film including a polyimide-polybenzoxazole copolymer including a repeating unit represented by Chemical Formula 1: wherein in Chemical Formula 1, A1, A1′, A2, A3, m, and n are the same as described in the specification.

  一种薄膜，包括聚酰亚胺-聚苯并恶唑共聚物，其中包括化学式 1 所代表的重复单元： 其中化学式 1 中，A1、A1′、A2、A3、m 和 n 与说明书中所述相同。
• CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2379525B1

  公开（公告）日：2015-07-29
• 2-Substituted (2<i>SR</i>)-2-Amino-2-((1<i>SR</i>,2<i>SR</i>)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution
  作者：Paul L. Ornstein、Thomas J. Bleisch、M. Brian Arnold、Rebecca A. Wright、Bryan G. Johnson、Darryle D. Schoepp

  DOI：10.1021/jm970497w

  日期：1998.1.1

  In this paper, we describe the synthesis of a series of a-substituted analogues of the potent and selective group II metabotropic glutamate receptor (mGluR) agonist (1S,1'S,2'S)-carboxy-cyclopropylglycine (2, L-CCG 1). Incorporation of a substituent on the amino acid carbon converted the agonist 2 into antagonist. Ail of the compounds were prepared and tested as a series of four isomers, i.e., two racemic diastereomers. We explored alkyl substitution, both normal and terminally branched; phenylalkyl and diphenylalkyl substitution; and a variety of aromatic and carbocyclic surrogates for phenyl. Affinity for group II mGluRs was measured using [H-3]glutamic acid (Glu) binding in rat forebrain membranes. Antagonist activity was confirmed for these compounds by measuring their ability to antagonize (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibition of forskolin-stimulated cyclic-AMP in RGT cells transfected with human mGluR2 and mGluR3. We found that while alkyl substitution provided no increase in affinity relative to 2, phenylethyl and diphenylethyl substitution, as in 105 and 109, respectively, were quite beneficial, The affinity of 109 was further enhanced when the two aromatic rings were joined by an oxygen or sulfur atom to form the tricyclic xanthylmethyl and thioxanthylmethyl amino acids 113 and 114, respectively. Amino acid 113, with an IC50 of 0.10 mu M in the [H-3]Glu binding assay, was 52-fold more patent than 2, whose IC50 was 0.47 mu M.
• Barluenga, Jose; Gonzalez, Jose M.; Campos, Pedro J., Angewandte Chemie, 1988, vol. 100, # 11, p. 1604 - 1605
  作者：Barluenga, Jose、Gonzalez, Jose M.、Campos, Pedro J.、Asensio, Gregorio

  DOI：——

  日期：——