1,2-丙二醇,3-[(2-羟基乙基)甲基氨基]- | 101350-03-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,2-丙二醇,3-[(2-羟基乙基)甲基氨基]-
• 英文名称: 3-(N-Methyl-2-hydroxyethylamino)-1,2-propanediol
• 英文别名: 3-[(2-Hydroxyethyl)(methyl)amino]propane-1,2-diol；3-[2-hydroxyethyl(methyl)amino]propane-1,2-diol
• CAS: 101350-03-2
• 化学式: C₆H₁₅NO₃
• mdl: MFCD23713442
• 分子量: 149.19
• InChiKey: OMAZOQJFCULQBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  63.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,2-丙二醇,3-[(2-羟基乙基)甲基氨基]- 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 生成 N-(2-Chlorethyl)-N-methyl-2,3-dichlorpropylamin
  参考文献：
  名称：

  Ishidate,M. et al., Chemical and pharmaceutical bulletin, 1961, vol. 9, p. 485 - 491

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氯-1,2-丙二醇 、 N-甲基-2-羟基乙胺 生成 1,2-丙二醇,3-[(2-羟基乙基)甲基氨基]-
  参考文献：
  名称：

  GAGAUZOV J.; PEJKOV PL., FARMATSIYA, 36,(1986) N 4, 1-6

  摘要：

  DOI：

文献信息

• [EN] 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS<br/>[FR] COMPOSÉS ET COMPOSITIONS DE 5- (4- (HALOALKOXY) PHÉNYL) PYRIMIDINE-2-AMINE UTILISÉS COMME INHIBITEURS DE KINASES
  申请人：IRM LLC

  公开号：WO2009026276A1

  公开（公告）日：2009-02-26

  The invention provides compounds of formula (1) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, AbI, BCR-AbI, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3. Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, Fms, KDR, c-rapor b-raf kinases.

  该发明提供了式（1）的化合物及其制药组合物，可用作蛋白激酶抑制剂，以及使用这些化合物治疗、改善或预防与异常或调节的激酶活性相关的疾病的方法。在某些实施方式中，该发明提供了使用这些化合物来治疗、改善或预防涉及c-kit、PDGFRα、PDGFRβ、CSF1R、AbI、BCR-AbI、CSK、JNK1、JNK2、p38、p70S6K、TGFβ、SRC、EGFR、trkB、FGFR3、Fes、Lck、Syk、RAF、MKK4、MKK6、SAPK2β、BRK、Fms、KDR、c-RApor、b-RAf激酶的疾病或紊乱的方法。
• Diarylamine-Containing Compounds and Compositions, and their use as Modulators of C-Kit Receptors
  申请人：Molteni Valentina

  公开号：US20070149538A1

  公开（公告）日：2007-06-28

  Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

  本文描述了包含二芳胺结构特征的化合物。还描述了制备这种化合物的方法，使用这种化合物调节c-kit受体活性的方法，以及包含这种化合物的药物组合物和药物。本文还描述了使用这种化合物、药物组合物和药物治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或状况的方法。
• 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS
  申请人：ZENECA LIMITED

  公开号：EP0733045A1

  公开（公告）日：1996-09-25
• PROCESS FOR THE TREATMENT OF LIQUEFIED HYDROCARBONS USING 3-(AMINO) PROPANE-1,2-DIOL COMPOUNDS
  申请人：Dow Global Technologies LLC

  公开号：EP2861697B1

  公开（公告）日：2016-11-30
• Process For The Treatment Of Liquefied Hydrocarbon Gas Using 3-(Amino) Propane-1,2-Diol Compounds
  申请人：Dow Global Technologies LLC

  公开号：US20150141731A1

  公开（公告）日：2015-05-21

  A method for treating liquefied hydrocarbons including acid gases to remove the acid gases while minimizing loss of amine species, said method comprising the step of contacting the liquefied hydrocarbons with an absorbent aqueous solution of a first amine compound, the first amine compound having the structure wherein R 1 is propane-2,3-diol; R 2 is hydrogen, methyl, ethyl, 2-hydroxyethyl, or propane- 2,3 -diol; and R3 is hydrogen, methyl, ethyl, 2-hydroxyethyl or propane-2,3-diol.