1,2-乙二胺,N,N-二(2-甲氧基乙基)- | 116763-69-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,2-乙二胺,N,N-二(2-甲氧基乙基)-
• 英文名称: N¹,N¹-Bis-(2-methoxy-ethyl)-ethane-1,2-diamine
• 英文别名: (2-Aminoethyl)bis(2-methoxyethyl)amine；N',N'-bis(2-methoxyethyl)ethane-1,2-diamine
• CAS: 116763-69-0
• 化学式: C₈H₂₀N₂O₂
• mdl: MFCD06446845
• 分子量: 176.259
• InChiKey: QFKPHGNNLPBQDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,2-乙二胺,N,N-二(2-甲氧基乙基)- 在 sodium cyanoborohydride 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 生成 N-[(2-Amino-5-chloro-phenyl)-(2-chloro-phenyl)-methyl]-N',N'-bis-(2-methoxy-ethyl)-ethane-1,2-diamine
  参考文献：
  名称：

  Efficient Syntheses of Benzothiazepines as Antagonists for the Mitochondrial Sodium−Calcium Exchanger:  Potential Therapeutics for Type II Diabetes

  摘要：

  Type II diabetes mellitus is a chronic metabolic disorder that can lead to serious cardiovascular, renal, neurologic, and retinal complications. While several drugs are currently prescribed to treat type II diabetes, their efficacy is limited by mechanism-related side effects (weight gain, hypoglycemia, gastrointestinal distress), inadequate efficacy for use as monotherapy, and the development of tolerance to the agents. Consequently, combination therapies are frequently employed to effectively regulate blood glucose levels. We have focused on the mitochondrial sodium-calcium exchanger (mNCE) as a novel target for diabetes drug discovery. We have proposed that inhibition of the mNCE can be used to regulate calcium flux across the mitochondrial membrane, thereby enhancing mitochondrial oxidative metabolism, which in turn enhances glucose-stimulated insulin secretion (GSIS) in the pancreatic beta-cell. In this paper, we report the facile synthesis of benzothiazepines and derivatives by S-alkylation using 2-aminobenzhydrols. The syntheses of other bicyclic analogues based on benzothiazepine, benzothiazecine, benzodiazecine, and benzodiazepine templates are also described. These compounds have been evaluated for their inhibition of mNCE activity, and the results from the structure-activity relationship (SAR) studies are discussed.

  DOI：

  10.1021/jo020446t
• 作为产物：
  描述：

  2-(bis(2-methoxyethyl)amino)acetonitrile 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 1,2-乙二胺,N,N-二(2-甲氧基乙基)-
  参考文献：
  名称：

  [EN] PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS
  [FR] PYRAZOLOTHIAZOLE CARBOXAMIDES ET LEURS UTILISATIONS EN TANT QU'INHIBITEURS DE PDGFR

  摘要：

  本公开涉及式(I)的化合物及其药学上可接受的盐。还描述了包含式(I)化合物的制药组合物，以及它们的使用和制备方法。

  公开号：

  WO2022136509A1

文献信息

• Y-SHAPE BRANCHED HYDROPHILIC POLYMER DERIVATIVES, THEIR PREPARATION METHODS, CONJUGATES OF THE DERIVATIVES AND DRUG MOLECULES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE CONJUGATES
  申请人：Ji Shishan

  公开号：US20110243892A1

  公开（公告）日：2011-10-06

  The present invention relates to Y-shape branched PEG derivatives of formulae (I) to (IV). The present invention also relates to conjugates of these Y-shape derivatives and drug molecules, pharmaceutical compositions comprising those conjugates.

  本发明涉及式（I）到式（IV）的Y形分支PEG衍生物。本发明还涉及这些Y形衍生物和药物分子的结合物，以及包含这些结合物的制药组合物。
• Kinase inhibitors
  申请人：CHIESI FARMACEUTICI S.p.A.

  公开号：US10364245B2

  公开（公告）日：2019-07-30

  Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

  本文定义的式 (I) 化合物是 p38 MAPK 抑制剂，可用作治疗呼吸道疾病等的抗炎剂。
• HARTMAN, GEORGE D.;PRUGH, JOHN D.
  作者：HARTMAN, GEORGE D.、PRUGH, JOHN D.

  DOI：——

  日期：——
• ANILINE DERIVATIVES
  申请人：ZENECA LIMITED

  公开号：EP0790986B1

  公开（公告）日：1999-01-20
• KINASE INHIBITORS
  申请人：CHIESI FARMACEUTICI S.p.A.

  公开号：US20180354945A1

  公开（公告）日：2018-12-13

  Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.