1,2-二羟基-5,8-二[(4-甲基苯基)氨基]-9,10-蒽二酮 | 6636-38-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 1,2-二羟基-5,8-二[(4-甲基苯基)氨基]-9,10-蒽二酮
• 英文名称: 1,2-Dihydroxy-5,8-bis[(4-methylphenyl)amino]anthracene-9,10-dione
• 英文别名: 1,2-dihydroxy-5,8-bis(4-methylanilino)anthracene-9,10-dione
• CAS: 6636-38-0
• 化学式: C₂₈H₂₂N₂O₄
• 分子量: 450.5
• InChiKey: SYLQIUPVHTXOJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  98.7
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• System and method for electrochemical detection of biological compounds
  申请人：Althaus S. John

  公开号：US20060207891A1

  公开（公告）日：2006-09-21

  The present invention relates to an electrochemical method for detecting a target polynucleotide. An electrode comprising an electrode surface is provided. The electrode surface includes at least one probe molecule reverisbly immobilized with respect to the electrode surface. A first electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The electrode surface is contacted with a liquid comprising the target polynucleotide. Upon the contacting step, at least some of the probe molecule immobilized with respect to the electrode surface dissociates therefrom. A second electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The presence of the target polynucleotide is determined at least partially on the basis of the first and second electrochemical signals.

  本发明涉及一种检测目标多核苷酸的电化学方法。提供了一种包括电极表面的电极。电极表面包括至少一个相对于电极表面可逆固定的探针分子。可获得指示相对于电极表面固定的探针分子量的第一电化学信号。电极表面与含有目标多核苷酸的液体接触。在接触步骤中，相对于电极表面固定的探针分子至少有一部分从电极表面解离。获得指示相对于电极表面固定的探针分子量的第二电化学信号。目标多核苷酸的存在至少部分是根据第一和第二电化学信号确定的。
• SYSTEM AND METHOD FOR ELECTROCHEMICAL DETECTION OF BIOLOGICAL COMPOUNDS
  申请人：Althaus John S.

  公开号：US20110039345A1

  公开（公告）日：2011-02-17

  The present invention relates to an electrochemical method for detecting a target polynucleotide. An electrode comprising an electrode surface is provided. The electrode surface includes at least one probe molecule reversibly immobilized with respect to the electrode surface. A first electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The electrode surface is contacted with a liquid comprising the target polynucleotide. Upon the contacting step, at least some of the probe molecule immobilized with respect to the electrode surface dissociates therefrom. A second electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The presence of the target polynucleotide is determined at least partially on the basis of the first and second electrochemical signals.
• COMPOSITIONS AND METHODS FOR BONE FORMATION AND MODELING
  申请人：ENZO Biochem, Inc.

  公开号：US20130172332A1

  公开（公告）日：2013-07-04

  The present disclosure is directed to methods of identifying a compound that binds to or interacts with a protein receptor involved in bone formation. Specifically, the disclosure is directed to methods of identifying a compound that regulates a Wnt pathway in a cell by binding to or interacting with cavities in proteins such as LRP5, LRP 6 and/or frizzled receptor and interfering with receptor binding to other proteins in a Wnt pathway. The present disclosure is further directed to methods and compositions that comprise an identified compound for treating or preventing a disease in a mammal in which Wnt pathway suppression plays a role.
• US7820030B2
  申请人：——

  公开号：US7820030B2

  公开（公告）日：2010-10-26
• US8105477B2
  申请人：——

  公开号：US8105477B2

  公开（公告）日：2012-01-31