1,2-苯二醇,4-((2-((二甲氨基)甲基)苯基)硫代)-,(Z)-2-丁烯二酸酯(1:1)(salt) | 70862-11-2

• 物质功能分类: 生物 - 生物化学试剂
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,2-苯二醇,4-((2-((二甲氨基)甲基)苯基)硫代)-,(Z)-2-丁烯二酸酯(1:1)(salt)
• 英文名称: thermospermine
• 英文别名: N-(4-Aminobutyl)-N'-(3-aminopropyl)-1,3-diaminopropan; Thermospermin；Thermospermin；N'-[3-(3-aminopropylamino)propyl]butane-1,4-diamine
• CAS: 70862-11-2
• 化学式: C₁₀H₂₆N₄
• 分子量: 202.343
• InChiKey: DODDBCGMRAFLEB-UHFFFAOYSA-N

物化性质

• 沸点：
  330.9±10.0 °C(Predicted)
• 密度：
  0.925±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（轻微，超声处理）、甲醇（非常轻微）、水（少量）

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  14
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  76.1
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N¹,N⁴-Methylenespermidine 在 盐酸 、 sodium tetrahydroborate 作用下， 以 甲醇 、 乙醇 、 苯 为溶剂， 反应 23.0h， 生成 1,2-苯二醇,4-((2-((二甲氨基)甲基)苯基)硫代)-,(Z)-2-丁烯二酸酯(1:1)(salt)
  参考文献：
  名称：

  天然存在的多胺的化学性质。全合成热精胺

  摘要：

  区分亚精胺类似碱基的方法学导致了热精胺的首次合成。

  DOI：

  10.1016/0040-4039(80)80103-1

文献信息

• LINEAR GLYCIDYL CARBAMATE (GC) RESINS FOR HIGHLY FLEXIBLE COATINGS
  申请人：NDSU RESEARCH FOUNDATION

  公开号：US20150099128A1

  公开（公告）日：2015-04-09

  This invention relates to coating compositions comprising a linear glycidyl carbamate (GC) resin and a curing agent. The linear GC-resins were synthesized using linear and cycloaliphatic diisocyanates and a combination of diols and optional triols with glycidol. The combination of linear diisocyanates and diols introduces a more linear structure in the GC-resin compositions.

  本发明涉及一种包含线性环氧丙烯酸酯（GC）树脂和固化剂的涂料组合物。线性GC树脂使用线性和环脂肪族二异氰酸酯以及二元醇和可选的三元醇与环氧丙醇一起合成。线性二异氰酸酯和二元醇的组合在GC树脂组合物中引入了更线性的结构。
• Novel polyamine analogues as therapeutic and diagnostic agents
  申请人：ORIDIGM CORPORATION

  公开号：EP1085011A1

  公开（公告）日：2001-03-21

  Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating disease where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinatorial polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.

  本发明揭示了具有比已知化合物低两个数量级的抑制常数的多胺转运抑制剂。这些多胺类似物是治疗需要抑制多胺转运或其他多胺结合蛋白的疾病的有用药物，例如癌症和血管成形术后的损伤。揭示了获得多胺类似物的新的化学合成方法，包括制备组合多胺库。这些方法产生的类似物具有理想的诊断和研究测定和治疗活性。本发明的测定方法对于高通量筛选与多胺系统相互作用的药物发现目标非常有用。
• Polyamine analogues as therapeutic and diagnostic agents
  申请人：MediQuest Therapeutics, Inc.

  公开号：EP1867633A1

  公开（公告）日：2007-12-19

  Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinatorial polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.

  本研究公开了新型多胺转运抑制剂，其抑制常数比已知化合物的抑制常数低两个数量级。这些多胺类似物是治疗需要抑制多胺转运或其他多胺结合蛋白的疾病（如癌症和血管成形术后损伤）的有用药物。公开了获得多胺类似物的新型化学合成方法，包括组合多胺库的生产。这些方法产生的类似物具有理想的活性，既可用于诊断和研究测定，也可用于治疗。本发明的检测方法可用于高通量筛选目标，以发现与多胺系统相互作用的药物。
• INJECTION DEVICES COMPRISING A COMPOSITION OF HYALURONIC ACID AND MEPIVACAINE HYDROCHLORIDE
  申请人：Teoxane

  公开号：EP3574901A1

  公开（公告）日：2019-12-04

  The present invention relates to an injection device suitable for intraepidermal and/or intradermally and/or subcutaneously comprising a sterile and injectable composition, said composition being prepared by a method comprising at least the steps of: a) providing at least one gel of a hyaluronic acid or a salt thereof, said hyaluronic acid being selected from a crosslinked hyaluronic acid form, a non-crosslinked hyaluronic acid form or a mixture thereof; b) adding to said gel of hyaluronic acid at least mepivacaine hydrochloride as anesthetic agent; and c) sterilizing the mixture obtained in step b).

  本发明涉及一种适用于表皮内和（或）皮内和（或）皮下的注射装置，该装置由无菌可注射组合物组成，所述组合物的制备方法至少包括以下步骤： a) 提供至少一种透明质酸凝胶或其盐，所述透明质酸选自交联透明质酸、非交联透明质酸或其混合物； b) 向所述透明质酸凝胶中添加至少盐酸甲哌卡因作为麻醉剂；以及 c) 对步骤 b) 中得到的混合物进行灭菌。
• IMMUNOSUPPRESSIVE LEUKOCYTE ADSORPTION MATERIAL AND ADSORPTION COLUMN
  申请人：Toray Industries, Inc.

  公开号：EP3679964A1

  公开（公告）日：2020-07-15

  An objective of the present disclosure is to provide an adsorption material that can selectively adsorb immunosuppressive leukocyte. The present disclosure provides an adsorption material for immunosuppressive leukocyte. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae are bound. A form of the water-insoluble carrier is a fiber or a particle, a diameter of the fiber or the particle is 15 to 50 µm, and an arithmetic mean roughness of a surface of the water-insoluble carrier is 0.1 to 3.0 µm.

  本公开的目的是提供一种可选择性吸附免疫抑制性白细胞的吸附材料。本公开提供了一种用于免疫抑制白细胞的吸附材料。该吸附材料包括一种水不溶性载体，在该载体上结合了至少一种选自预定式所代表的多胺和预定式所代表的脂肪胺的含氮化合物。水不溶性载体的形式为纤维或颗粒，纤维或颗粒的直径为 15 至 50 微米，水不溶性载体表面的算术平均粗糙度为 0.1 至 3.0 微米。