Isonicotinic acid [2,2,2-trifluoro-1-phenyl-eth-(E)-ylidene]-hydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Isonicotinic acid [2,2,2-trifluoro-1-phenyl-eth-(E)-ylidene]-hydrazide
• 英文别名: N-[(E)-(2,2,2-trifluoro-1-phenyl-ethylidene)amino]pyridine-4-carboxamide；N-[(E)-(2,2,2-trifluoro-1-phenylethylidene)amino]pyridine-4-carboxamide
• 化学式: C₁₄H₁₀F₃N₃O
• 分子量: 293.248
• InChiKey: HSLNJPGFVWIQSL-XDHOZWIPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  异烟肼 、 2,2,2-三氟苯乙酮 以 乙醇 为溶剂， 生成 Isonicotinic acid [2,2,2-trifluoro-1-phenyl-eth-(E)-ylidene]-hydrazide
  参考文献：
  名称：

  Antimycobacterial in vitro activity of cobalt(ii) isonicotinoylhydrazone complexes. Part 10

  摘要：

  Octahedral cobalt(II) complexes of isonicotinoylhydrazones. which were obtained from the primary antituberculous agent isoniazid, have been synthesised and characterised. Their antimycobacterial in vitro activity has been evaluated against Mycobacterium tuberculosis H37Rv: they exhibit MIC values ranging from < 0.1 to 0.19 g/mL, showing them to be generally more active than previously reported analogous Cu(II) and NI(II) complexes, (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00648-x

文献信息

• Antimycobacterial in vitro activity of cobalt(ii) isonicotinoylhydrazone complexes. Part 10
  作者：B. Bottari、R. Maccari、F. Monforte、R. Ottanà、E. Rotondo、M.G. Vigorita

  DOI：10.1016/s0960-894x(00)00648-x

  日期：2001.2

  Octahedral cobalt(II) complexes of isonicotinoylhydrazones. which were obtained from the primary antituberculous agent isoniazid, have been synthesised and characterised. Their antimycobacterial in vitro activity has been evaluated against Mycobacterium tuberculosis H37Rv: they exhibit MIC values ranging from < 0.1 to 0.19 g/mL, showing them to be generally more active than previously reported analogous Cu(II) and NI(II) complexes, (C) 2001 Elsevier Science Ltd. All rights reserved.