1,3-二溴-5,5-二苯基咪唑烷-2,4-二酮 | 92426-30-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 1,3-二溴-5,5-二苯基咪唑烷-2,4-二酮
• 英文名称: 1,3-dibromo-5,5-diphenylimidazolidine-2,4-dione
• 英文别名: 1,3-dibromo-5,5-diphenylhydantoin；N,N-dibromophenytoin；DBDPH；1,3-dibromo-5,5-diphenyl-imidazolidine-2,4-dione；1,3-Dibrom-5,5-diphenyl-imidazolidin-2,4-dion；N,N'-dibromo-5,5-diphenylhydantoin
• CAS: 92426-30-7
• 化学式: C₁₅H₁₀Br₂N₂O₂
• 分子量: 410.065
• InChiKey: YHELUCUIFBBFGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  苯妥英 在 sodium hydroxide 、 溴 作用下， 生成 1,3-二溴-5,5-二苯基咪唑烷-2,4-二酮
  参考文献：
  名称：

  Orazi et al., Anales des la Asociacion Quimica Argentina, 1952, vol. 40, p. 109

  摘要：

  DOI：
• 作为试剂：
  描述：

  2-氯硫代苯甲酰胺 在 1,3-二溴-5,5-二苯基咪唑烷-2,4-二酮 、 水 作用下， 反应 0.1h， 以94%的产率得到3,5-双(2-氯苯基)-1,2,4-噻二唑
  参考文献：
  名称：

  Highly Efficient Synthesis of 3,5-Diaryl-1,2,4-thiadiazoles in Water–Wet Paste Conditions

  摘要：

  1,3-Dibromo-5,5-diphenylimidazolidine-2,4-dione (N,N'-dibromo phenytoin) was efficiently used for the rapid conversion of thiobenzamides to the corresponding 3,5-diaryl-1,2,4-thiadiazoles in water-wet paste conditions. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.

  DOI：

  10.1080/00397911.2010.515368

文献信息

• [EN] PROCESS FOR THE PREPARATION OF ORGANIC BROMIDES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE BROMURES ORGANIQUES
  申请人：TECHNION RES & DEV FOUNDATION

  公开号：WO2017060905A1

  公开（公告）日：2017-04-13

  The present invention provides a process for the preparation of organic bromides, by a radical bromodecarboxylation of carboxylic acids with a bromoisocyanurate.

  本发明提供了一种有机溴化物的制备方法，通过使用溴异氰酸酯对羧酸进行自由基溴脱羧化反应。
• Benzoamide piperidine containing compounds and related compounds
  申请人：——

  公开号：US20030087925A1

  公开（公告）日：2003-05-08

  The present invention relates to certain benzoamide piperidine containing compounds and related compounds that exhibit activity as NK-1 receptor antagonists, (e.g., substance P receptor antagonists), to pharmaceutical compositions containing them, and to their use in the treatment and prevention of central nervous system disorders, inflammatory disorders, cardiovascular disorders, ophthalmic disorders, gastrointestinal disorders, disorders caused by helicobacter pylori, disorders of the immune system, urinary incontinence, pain, migraine, emesis, angiogenesis and other disorders.

  本发明涉及某些含有苯甲酰胺哌啶类化合物和相关化合物，这些化合物表现出作为NK-1受体拮抗剂（例如，物质P受体拮抗剂）的活性，以及含有它们的药物组合物，以及它们在治疗和预防中枢神经系统疾病、炎症性疾病、心血管疾病、眼科疾病、消化系统疾病、幽门螺杆菌引起的疾病、免疫系统疾病、尿失禁、疼痛、偏头痛、呕吐、血管生成和其他疾病的治疗中的用途。
• PROCESS FOR THE PREPARATION OF SUVOREXANT AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF SUVOREXANT
  申请人：DR. REDDY'S LABORATORIES LIMTED

  公开号：US20160168138A1

  公开（公告）日：2016-06-16

  A novel processes for the preparation of suvorexant (formula I), its related compounds and its intermediates that are simple, economical and commercially viable. (I)

  一种用于制备苏维瑞昔安（化学式I）、其相关化合物和中间体的新工艺，简单、经济且具有商业可行性。 (I)
• Process for brominating the side chain of 4-methylbiphenyl derivatives substituted in the 2' position
  申请人：——

  公开号：US20020095042A1

  公开（公告）日：2002-07-18

  A process for preparing 4-bromomethylbiphenyl derivatives substituted in the 2′ position of general formula (I) 1 by brominating 4-methylbiphenyl derivatives substituted in the 2′ position of general formula (II) 2 wherein: R is CN, COOR 1, CONR 1 R 2 , or C(OR 3 )═NR 4 , or 5-tetrazolyl optionally substituted by benzyl, methyloxycarbonyl, ethyloxycarbonyl, 9 -fluorenylmethyloxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, benzyloxycarbonyl, tert-butyloxycarbonyl, allyloxycarbonyl, trichloroacetyl, trifluoroacetyl, or trityl; R 1 and R 2 which are identical or different are hydrogen or C 1 -C 6 -alkyl; R 3 and R 4 together are a C 2 -C 3 -alkylene bridge optionally mono-, di-, tri-, or tetra- substituted by one or more of the groups methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, phenyl, or naphthyl, wherein the brominating is carried out by means of an N-bromoimide or N-bromoamide in a solvent of organic carboxylic acid esters.

  一种制备2'位置取代的4-溴甲基联苯衍生物的方法，通过对2'位置取代的4-甲基联苯衍生物进行溴化，通式(I)为：其中：R为CN、COOR1、CONR1R2或C(OR3)HNR4，或者选择性地被苄基、甲氧羰基、乙氧羰基、9-芴甲氧羰基、2,2,2-三氯乙氧羰基、苄氧羰基、叔丁氧羰基、烯丙氧羰基、三氯乙酰基、三氟乙酰基或三苄基取代的5-四唑基；R1和R2相同或不同，为氢或C1-C6-烷基；R3和R4共同形成C2-C3烷基桥，可选择性地通过一个或多个甲基、乙基、正丙基、异丙基、正丁基、异丁基、叔丁基、苯基或萘基取代一次、二次、三次或四次，溴化通过有机羧酸酯溶剂中的N-溴代亚胺或N-溴代酰胺进行。
• ACCESS TO CHIRAL BISPHENOL (BPOL) LIGANDS THROUGH DESYMMETRIZING ASYMMETRIC ORTHO-SELECTIVE MONO-HALOGENATION
  申请人：The Chinese University of Hong Kong

  公开号：US20210300853A1

  公开（公告）日：2021-09-30

  The subject invention pertains to a method of halogenating phenols, yielding a range of halogenated phenols with enantiomeric ratio of up to 99.5:0.5. In certain embodiments, the subject invention pertains to a method of asymmetric halogenation of bisphenol, yielding a range of chiral bisphenol ligands. The novel chiral bisphenols are potent privileged catalyst cores that can be applied to the preparation of ligands for various catalytic asymmetric reactions. The catalyst library can easily be accessed because late-stage modification of the scaffold can readily be executed through cross-coupling of the halogen handles on the bisphenols.

  本发明涉及一种卤代酚的卤代方法，可产生范围广泛的卤代酚，其对映比可高达99.5:0.5。在某些实施例中，本发明涉及一种不对称卤代双酚的方法，可产生一系列手性双酚配体。新型手性双酚是有效的特权催化剂核心，可应用于各种催化不对称反应的配体制备。因为可以通过交叉偶联双酚上的卤素手柄进行骨架的后期修饰，所以可以轻松地访问催化剂库。

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