N1-phenyl-5-(2-(2-thienyl)vinyl)-1H-pyrazole-1-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N1-phenyl-5-(2-(2-thienyl)vinyl)-1H-pyrazole-1-carboxamide
• 英文别名: N-phenyl-5-[(E)-2-thiophen-2-ylethenyl]pyrazole-1-carboxamide
• 化学式: C₁₆H₁₃N₃OS
• 分子量: 295.365
• InChiKey: XESFYGSPMQKAMH-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES
  申请人：Paka Latha

  公开号：US20100256117A1

  公开（公告）日：2010-10-07

  Methods are provided for treating fibrotic connective tissue diseases such as scleroderma and conditions such as surgically-induced adhesions using compounds that activate the signaling pathways of hepatocyte growth factor.
• HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN DEMYELINATING DISEASES AND CENTRAL NERVOUS SYSTEM TRAUMA
  申请人：Yuzhakov Alexander

  公开号：US20110230407A1

  公开（公告）日：2011-09-22

  Methods are provided for treating and preventing demyelinating diseases including multiple sclerosis, and traumatic injury to the central nervous system including brain trauma and spinal cord injury, by administering a compound or pharmaceutical composition of the invention. Useful compounds include hepatocyte growth factor/scatter factor protein, fragments, fusion polypeptides and muteins thereof, and nucleic acid and expression vectors encoding such proteins. Other useful compounds include small molecule HGF/SF agonists and mimetics.
• US7879898B1
  申请人：——

  公开号：US7879898B1

  公开（公告）日：2011-02-01
• US8193177B2
  申请人：——

  公开号：US8193177B2

  公开（公告）日：2012-06-05