1,4-哌嗪二丙磺酸 | 5625-56-9

• 物质功能分类: 化学试剂 - 有机试剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1,4-哌嗪二丙磺酸
• 英文名称: 1,4-bis(3-sulfopropyl)piperazinium
• 英文别名: PIPPS；3,3'-piperazine-1,4-diyl-bis-propane-1-sulfonic acid；piperazine-1,4-dipropanesulfonic acid；1,4-Bis-<3-sulfo-propyl>-piperazin；1,4-Piperazinedipropanesulfonic acid；3-[4-(3-sulfopropyl)piperazin-1-yl]propane-1-sulfonic acid
• CAS: 5625-56-9
• 化学式: C₁₀H₂₂N₂O₆S₂
• 分子量: 330.426
• InChiKey: PDLPTSJWDUCMKS-UHFFFAOYSA-N

物化性质

• 熔点：
  >400 °C (decomp)
• 密度：
  1.413±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -6.3
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  8

安全信息

• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  1,4-哌嗪二丙磺酸 在 磷酸 作用下， 以 水 为溶剂， 反应 5.0h， 生成 1,4-bis(3-sulfopropyl)piperazinium bis(hydrogenphosphate)
  参考文献：
  名称：

  Novel bi-SO3H-functionalized ionic liquids based on piperazinium: Highly efficient and recyclable catalysts for the synthesis of β-acetamido ketones

  摘要：

  A series of novel bi-SO3H-functionalized ionic liquids were synthesized and acted as catalysts for the synthesis of beta-acetamido ketones. Compared with traditional single-SO3H-functionalized ionic liquids, less amount of catalysts, higher yields and shorter reaction time are the key features of this methodology. Hammett function values and the minimum-energy geometries of bi-SO3H-functionalized ILs were calculated and the results revealed that the acidities and catalytic activities of ILs in synthesis of beta-acetamido ketones were influenced by their structures. The IL[(PS)(2)pi][OTf](2) with the shortest H-O bond distance had the strongest acidity and the highest catalytic activity. (c) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2012.09.023
• 作为产物：
  描述：

  哌嗪 、 1,3-丙烷磺内酯 在 水 作用下， 反应 0.17h， 生成 1,4-哌嗪二丙磺酸
  参考文献：
  名称：

  Novel bi-SO3H-functionalized ionic liquids based on piperazinium: Highly efficient and recyclable catalysts for the synthesis of β-acetamido ketones

  摘要：

  A series of novel bi-SO3H-functionalized ionic liquids were synthesized and acted as catalysts for the synthesis of beta-acetamido ketones. Compared with traditional single-SO3H-functionalized ionic liquids, less amount of catalysts, higher yields and shorter reaction time are the key features of this methodology. Hammett function values and the minimum-energy geometries of bi-SO3H-functionalized ILs were calculated and the results revealed that the acidities and catalytic activities of ILs in synthesis of beta-acetamido ketones were influenced by their structures. The IL[(PS)(2)pi][OTf](2) with the shortest H-O bond distance had the strongest acidity and the highest catalytic activity. (c) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2012.09.023
• 作为试剂：
  描述：

  氨氧基-一聚乙二醇-叠氮 、 GYSIFSYATK 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 1,4-哌嗪二丙磺酸 作用下， 生成
  参考文献：
  名称：

  COMPOUNDS AND METHODS FOR SELECTIVE C-TERMINAL LABELING

  摘要：

  本公开涉及化合物和方法，用于选择性地对肽的C-末端进行功能化。在某些实施例中，这些化合物具有改善的水溶性，并适用于与肽测序方法相关的应用。

  公开号：

  US20210221839A1

文献信息

• METAL-ORGANIC FRAMEWORK PHASE AND CRYSTALLITE SHAPE CONTROL
  申请人：The Regents of the University of California

  公开号：US20200101439A1

  公开（公告）日：2020-04-02

  Methods of synthesizing crystalline metal-organic frameworks (MOFs) comprising polytopic organic linkers and cations, where each linker is connected to two or more cations, are provided. In the disclosed methods, the linkers are reacted with a compound of formula M n X m , where M is cationic Be, Mg, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Zr, Nb, Mo, Ru, Rh, Pd, Cd, or Hf, X is anionic, n and m are integers. The reacting is buffered by a buffer devoid of metal coordinating functionality when the pKa of the anion is below a threshold related to the lowest pKa of the linker. The reacting is optionally not buffered when the pKa of the anion is at or above this threshold. The disclosed methods lead to product phase MOF in which crystal growth is controlled leading to control over molecular diffusion.

  提供了一种合成包含多面体有机连接物和阳离子的结晶金属-有机框架（MOFs）的方法，其中每个连接物连接到两个或更多的阳离子。在所公开的方法中，连接物与式为MnXm的化合物反应，其中M为阳离子Be、Mg、Ca、Ti、V、Cr、Mn、Fe、Co、Ni、Cu、Zn、Zr、Nb、MO、Ru、Rh、Pd、Cd或Hf，X为阴离子，n和m为整数。当阴离子的pKa低于与连接物最低pKa相关的阈值时，反应由不具有金属配位功能的缓冲剂缓冲。当阴离子的pKa在或高于此阈值时，反应可以选择不缓冲。所公开的方法导致产物相MOF，其中晶体生长受控制，从而控制分子扩散。
• Stabilization of cholinesterase, detector kit using stabilized
  申请人：Midwest Research Institute

  公开号：US04324858A1

  公开（公告）日：1982-04-13

  The stability of a cholinesterase (particularly a cholinesterase solution impregnated into a porous material and air-dried) can be improved by: (a) buffering the cholinesterase solution with a zwitterionic buffer, e.g. a buffer having a sulfonic acid group and a protonatable amine group, and, preferably, (b) further drying the impregnated, air-dried porous material under a high vacuum (e.g. 0.01 mm Hg or less) at normal ambient temperatures. The most useful porous materials are sheet-like in nature; that is, they have only two major surfaces. An impregnated, sheet-like material of this invention can be used in a cholinesterase inhibitor detector kit. A typical kit of this type provides a simple means for detecting, inter alia, environmental cholinesterase-inhibiting pollutant, e.g. organophosphorous pesticides and nerve agents.

  胆碱酯酶的稳定性（特别是浸渍到多孔材料中并经过空气干燥的胆碱酯酶溶液）可以通过以下方法改善：（a）使用带有磺酸基和可质子化胺基的游离离子缓冲剂缓冲胆碱酯酶溶液，并且最好（b）在正常环境温度下，在高真空下（例如0.01毫米汞柱或更低）进一步干燥浸渍的、经过空气干燥的多孔材料。最有用的多孔材料是类似于薄片的材料；也就是说，它们只有两个主要表面。本发明的浸渍的类似薄片的材料可以用于胆碱酯酶抑制剂检测器套件。这种类型的典型套件提供了一种简单的方法来检测环境中的胆碱酯酶抑制剂污染物，例如有机磷杀虫剂和神经毒剂。
• Methods and compositions for treating amyloid-related diseases
  申请人：Kong Xianqi

  公开号：US20080015180A1

  公开（公告）日：2008-01-17

  Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-+related disease.

  本发明涉及用于治疗或预防淀粉样蛋白相关疾病的方法、化合物、制药组合物和试剂盒。
• Methods and Compositions for Treating Amyloid-Related Diseases
  申请人：KONG Xianqi

  公开号：US20100190753A1

  公开（公告）日：2010-07-29

  Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-+related disease.

  本文描述了用于治疗或预防淀粉样蛋白相关疾病的方法、化合物、药物组合物和试剂盒。
• PRANOPROFEN EYEDROPS CONTAINING ORGANIC AMINE
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：EP0824916A1

  公开（公告）日：1998-02-25

  The present ophthalmic solution is a pranoprofen ophthalmic solution containing an organic amine. A preferred ophthalmic solution is a 0.01 to 0.5% pranoprofen ophthalmic solution containing 0.1 to 5.0% of the organic amine. The concentration of the organic amine is more preferably 0.5 to 2.5%. A preferred example of the organic amine is tromethamine or 4-(2-hydroxyethyl)-1-(2-sulfoethyl)piperazine. Optionally, 0.002 to 0.01% benzalkonium chloride is added thereto as a preserative. According to the present invention, there can be provided an ophthalmic solution having pranoprofen as an active ingredient, which has no change in composition, excellent stability and little irritation to eyes.

  本眼药水是一种含有有机胺的普拉洛芬眼药水。优选的眼用溶液是含有 0.1 至 5.0%有机胺的 0.01 至 0.5%普拉洛芬眼用溶液。有机胺的浓度更优选为 0.5%至 2.5%。有机胺的一个优选例子是曲美他敏或 4-(2-羟乙基)-1-(2-磺乙基)哌嗪。可选择添加 0.002-0.01% 的苯扎氯铵作为防腐剂。 根据本发明，可以提供一种以普拉洛芬为有效成分的眼科溶液，该溶液成分不变，稳定性好，对眼睛刺激小。