1,8,15,22-四(苯硫醇)-29H,31H-酞菁 | 77492-98-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 中文名称: 1,8,15,22-四(苯硫醇)-29H,31H-酞菁
• 中文别名: 1,8,15,22-四(苯巯基)-29H.31H酞青；1,8,15,22-四(苯巯基)-29H,31H-酞菁
• 英文名称: tetra-3-(phenylthio)phthalocyanine
• 英文别名: 5,14,23,32-Tetrakis(phenylsulfanyl)-2,11,20,29,37,38,39,40-octazanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1(37),2,4(9),5,7,10,12,14,16,18,20,22(27),23,25,28(38),29,31(36),32,34-nonadecaene
• CAS: 77492-98-9
• 化学式: C₅₆H₃₄N₈S₄
• 分子量: 947.204
• InChiKey: SZGLSFRWHKISCC-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C(lit.)
• 密度：
  1.55±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  14.6
• 重原子数：
  68
• 可旋转键数：
  8
• 环数：
  13.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  210
• 氢给体数：
  2
• 氢受体数：
  10

安全信息

• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  3-苯硫基邻苯二甲腈 在 异戊醇钠 作用下， 以 异戊醇 为溶剂， 以25%的产率得到1,8,15,22-四(苯硫醇)-29H,31H-酞菁
  参考文献：
  名称：

  Derkacheva, V. M.; Luk'yanets, E. A., Journal of general chemistry of the USSR, 1980, vol. 50, p. 1874 - 1878

  摘要：

  DOI：

文献信息

• Drug delivery system for use in the treatment of vascular and vessel-related pathologies
  申请人：Academisch Medisch Centrum

  公开号：EP2210590A1

  公开（公告）日：2010-07-28

  The present invention relates to a drug delivery system for use in the treatment of vascular and vessel-related pathologies, comprising a drug delivery platform that comprises at least one compound capable of exerting an effect on the formation and/or maintenance of a thrombus in the vessel to be treated. The platform is preferably formed by liposomes that are sterically stabilized by grafting of poly(ethylene glycol) onto the liposome surface. The liposomes may further comprise photosensitizers and targeting molecules. The liposomes may be thermosensitive. The compound is suitably tranexamic acid. The drug delivery system is preferably used for the treatment of port wine stains.

  本发明涉及一种用于治疗血管和血管相关病症的给药系统，该系统包括一个给药平台，该平台包含至少一种能够对待治疗血管中血栓的形成和/或维持产生影响的化合物。该平台最好由脂质体形成，脂质体表面接枝聚乙二醇使其立体稳定。脂质体可进一步包含光敏剂和靶向分子。脂质体可具有热敏性。化合物宜为氨甲环酸。该给药系统最好用于治疗波特酒渍。
• Target activated microtransfer
  申请人：Bonner F. Robert

  公开号：US20060172278A1

  公开（公告）日：2006-08-03

  A device for performing target activated transfer that includes a mounting surface for mounting a tissue sample; and a light source positioned to substantially uniformly irradiate both stained and unstained regions of the tissue sample with light energy that activates the reagent to selectively adhere the stained regions to a transfer surface. Also described is an automated system for transferring tissue from a tissue sample to a transfer substrate. The system includes means for holding a tissue section that includes targets specifically stained with an absorptive stain thereby resulting in a stained tissue surface, and a flexible transfer film that includes a lower thermoplastic layer in sufficient thermal contact with the stained tissue surface; an irradiating assembly configured to provide a predetermined uniform light dose to the entire tissue section; and means for applying a constant pressure to the transfer film during irradiation.

  一种用于执行靶向激活转移的装置，包括一个用于安装组织样本的安装面；以及一个光源，其定位是用光能基本均匀地照射组织样本的染色和未染色区域，从而激活试剂，使染色区域选择性地附着在转移表面上。还描述了一种自动系统，用于将组织样本中的组织转移到转移基底上。该系统包括用于容纳组织切片的装置，该切片包括用吸收性染色剂特别染色从而形成染色组织表面的目标，以及柔性转印膜，该转印膜包括与染色组织表面充分热接触的下热塑性层；辐照组件，该组件配置为向整个组织切片提供预定的均匀光剂量；以及在辐照期间向转印膜施加恒定压力的装置。
• DERKACHEVA V. M.; LUKYANETS E. A., ZH. OBSHCH. XIMII, 1980, 50, HO 10, 2313-2318
  作者：DERKACHEVA V. M.、 LUKYANETS E. A.

  DOI：——

  日期：——
• CONVEX GEOMETRY ADHESIVE FILM SYSTEM FOR LASER CAPTURE MICRODISSECTION
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP0991929B1

  公开（公告）日：2003-03-26
• TARGET ACTIVATED MICROTRANSFER
  申请人：Emmert-Buck Michael R.

  公开号：US20100190177A1

  公开（公告）日：2010-07-29

  A method of removing a target from a biological sample which involves placing a transfer surface in contact with the biological sample, and then focally altering the transfer surface to allow selective separation of the target from the biological sample. In disclosed embodiments, the target is a cell or cellular component of a tissue section and the transfer surface is a film that can be focally altered to adhere the target to the transfer surface. Subsequent separation of the film from the tissue section selectively removes the adhered target from the tissue section. The transfer surface is activated from within the target to adhere the target to the transfer surface, for example by heating the target to adhere it to a thermoplastic transfer surface. Such in situ activation can be achieved by exposing the biological sample to an immunoreagent that specifically binds to the target (or a component of the target). The immunoreagent can alter the transfer surface directly (for example with a heat generating enzyme carried by the immunoreagent), or indirectly (for example by changing a characteristic of the target). In some embodiments, the immunoreagent deposits a precipitate in the target that increases its light absorption relative to surrounding tissue, such that the biological specimen can be exposed to light to selectively heat the target. Alternatively, the immunoreagent is an immunofluorescent agent that carries a fluorophore that absorbs light and emits heat.