1-[(E)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]imidazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[(E)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]imidazole
• 化学式: C₁₁H₇Cl₃N₂
• 分子量: 273.549
• InChiKey: SJUMKSLKUSAHMX-IZZDOVSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• 1-(2-Aryl-2-halo-1-ethenyl)-1H-azoles
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0142190A2

  公开（公告）日：1985-05-22

  Novel 1-(2-aryl-2-halo-1-etheny))-1H-azoles of the the pharmaceutically acceptable acid-addition salts and possible stereochemically isomeric forms thereof, which compounds are anticonvulsant agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.

  新型 1-(2-芳基-2-卤代-1-乙烯基))-1H-唑的药学上可接受的酸加成盐及其可能的立体化学异构体形式，这些化合物是抗惊厥剂；含有此类化合物作为活性成分的药物组合物以及制备所述化合物和药物组合物的方法。
• Novel derivatives of gamma-cyclodextrin
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0197571A2

  公开（公告）日：1986-10-15

  Novel γ-cyclodextrin derivatives which are γ-cyclodextrin substituted with C1-C6 alkyl, hydroxy C1-C6 alkyl, carboxy C1-C6 alkyl or C1-C6 alkyloxycarbonylC,-C6 alkyl or mixed ethers thereof and their preparation. Compositions comprising such cyclodextrin derivatives and an active ingredient which is preferably a drug and the preparation of such compositions.

  用C1-C6烷基、羟基C1-C6烷基、羧基C1-C6烷基或C1-C6烷氧羰基C,-C6烷基或其混合醚取代的γ-环糊精新型衍生物及其制备方法。由此类环糊精衍生物和活性成分（最好是药物）组成的组合物及其制备方法。
• New method for the detection of specific binding agents and their corresponding bindable substances
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0227173A2

  公开（公告）日：1987-07-01

  A method of qualitatively or quantitatively determining a component of a complex formed between at least one specific binding agent and its corresponding bindable substance. Said method comprises labelling at least one component of said complex with a marker which is easier to determine than the complex itself, whereby the marker used consists of latex particles which can be detected visually either by colour or fluorescence. Preferably the marker consists of coloured or colourable latex particles and the determination is based on the colour characteristics of the latex particles as such or, in the instance that colourable latex particles are used, on the colour characteristics of the coloured particles derived therefrom. The colour, respectively fluorescence signal is, if necessary after development, easily detected and optionally quantified. The invention further comprises coloured or colourable latex particles coated with specific binding proteins and test kits containing the same.

  一种定性或定量测定至少一种特异性结合剂与其相应的可结合物质之间形成的复合物的组分的方法。该方法包括用一种比复合物本身更容易确定的标记物对复合物中的至少一种成分进行标记，其中使用的标记物由可通过颜色或荧光目测的乳胶颗粒组成。标记物最好由有色或有色胶乳颗粒组成，根据胶乳颗粒本身的颜色特征来确定，或者在使用有色胶乳颗粒的情况下，根据由此产生的有色颗粒的颜色特征来确定。如有必要，可在显影后对颜色和荧光信号进行检测和量化。本发明还包括涂有特异性结合蛋白的有色或有色胶乳颗粒以及含有这些颗粒的检测试剂盒。
• Method for depositing metal particles on a marker
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0293947A1

  公开（公告）日：1988-12-07

  An improved method for depositing metal particles on a marker which catalyzes the reduction of metal ions from a physical developer comprising a solution of metal ions, a molar excess of complexant in respect to the metal ions and a reducing agent. Said method being preferably employed for the detection of one or more components of an aggregate formed between a least one specific binding agent and its corresponding bindable substance by labelling at least one component of said aggregate with a marker and contacting said aggregate with a physical developer, whereby under influence of the marker a metal particle is formed which can be detected. Further the invention also relates to solutions and test-kits suited for carrying out the above mentioned method.

  一种在标记物上沉积金属颗粒的改进方法，该标记物可催化金属离子从物理显影剂中还原，物理显影剂包括金属离子溶液、相对于金属离子摩尔过量的络合剂和还原剂。本发明优选用于检测至少一种特异性结合剂与其相应的可结合物质之间形成的聚合体的一种或多种成分，方法是用标记物标记所述聚合体的至少一种成分，并将所述聚合体与物理显影剂接触，在标记物的影响下形成可检测的金属颗粒。此外，本发明还涉及适用于实施上述方法的溶液和测试套件。
• Derivatives of gamma-cyclodextrin
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0636634A1

  公开（公告）日：1995-02-01

  Novel γ-cyclodextrin derivatives which are γ-cyclodextrin substituted with C₁-C₆ alkyl, hydroxy C₁-C₆ alkyl, carboxy C₁-C₆ alkyl or C₁-C₆ alkyloxycarbonyl C₁-C₆ alkyl or mixed ethers thereof and their preparation.

  用 C₁-C₆ 烷基、羟基 C₁-C₆ 烷基、羧基 C₁-C₆ 烷基或 C₁-C₆ 烷氧羰基 C₁-C₆ 烷基或其混合醚取代的新型 γ-环糊精衍生物及其制备方法。