1,9-双(马来酰亚胺顺丁烯二酰亚胺)壬烷 | 38460-50-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1,9-双(马来酰亚胺顺丁烯二酰亚胺)壬烷
• 中文别名: Z-2-甲基-4-(萘-2-亚甲基)恶唑-5(4H)-一
• 英文名称: N,N'-Nonamethylendimaleinimid
• 英文别名: 1-[9-(2,5-Dioxopyrrol-1-yl)nonyl]pyrrole-2,5-dione
• CAS: 38460-50-3
• 化学式: C₁₇H₂₂N₂O₄
• 分子量: 318.373
• InChiKey: CKUARIJSQIFRQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2925190090

反应信息

• 作为产物：
  描述：

  以 1,1,2,2-四氯乙烷 为溶剂， 反应 12.0h， 以85%的产率得到1,9-双(马来酰亚胺顺丁烯二酰亚胺)壬烷
  参考文献：
  名称：

  An efficient reverse Diels–Alder approach for the synthesis of N-alkyl bismaleimides

  摘要：

  Bismaleimides are useful precursors for Diels-Alder reactions, Michael additions, and thiol-maleimide based conjugation for the synthesis of materials and polymers. Use of bismaleimide cross linkers for generating polymers, bioconjugate molecules, and useful imaging molecules is an active area of research. An efficient and practical synthetic protocol for N-alkyl bis-maleimide cross linkers starting from furan protected maleimide employing a reverse Diels-Alder reaction is reported. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.07.002

文献信息

• A new class of bradykinin antagonists: synthesis and in vitro activity of bissuccinimidoalkane peptide dimers
  作者：John C. Cheronis、Eric T. Whalley、Khe T. Nguyen、Shad R. Eubanks、Lisa G. Allen、Matthew J. Duggan、Sharon D. Loy、Kathryn A. Bonham、James K. Blodgett

  DOI：10.1021/jm00087a010

  日期：1992.5

  potency. Rank order of antagonist potency as a function of dimerization position is as follows: rat uterus, 6 greater than 5 greater than 0 greater than 2 greater than 1 greater than 3 much greater than 4, 7, 8, 9; guinea pig ileum, 6 greater than 5 greater than 3 greater than 2 greater than 1 greater than 0 much greater than 4, 7, 8, 9. Evaluation of the linker length as represented by the number of methylene

  对缓激肽（BK）拮抗剂D-Arg0-Arg1-Pro2-Hyp3-Gly4-Phe5-Ser6-D-Phe 7-Leu8-Arg9的二聚化进行了系统研究。该研究的第一部分涉及化合物，其中通过用半胱氨酸顺序替换每个氨基酸并与双马来酰亚胺基己烷交联来进行二聚化。这项研究的第二部分利用了一系列的双琥珀酰亚胺基烷烃二聚体，其中中间的亚甲基链系统地从n = 2变为n = 12，而二聚化的点在位置6保持不变。在两种不同的分离组织制剂中，BK诱导的平滑肌收缩：豚鼠回肠（GPI）和大鼠子宫（RU）。几种二聚体BK拮抗剂表现出卓越的活性和长效作用。另外，在4、7、8或9位的二聚化产生具有显着降低的效力的二聚体类似物。拮抗剂效价作为二聚化位置的函数的等级次序如下：大鼠子宫，大于6的6大于5，大于2的大于2，大于1的大于3，大于3的大于4、7、8、9；豚鼠回肠，大于6大于5大于3大于2大于1大于0大于4、7、8
• Phosphine-catalyzed, michael addition-curable sulfur-containing polymer compositions
  申请人：PRC-DeSoto International, Inc.

  公开号：US10011751B2

  公开（公告）日：2018-07-03

  Compositions comprising Michael acceptor-terminated sulfur-containing prepolymers, thiol-terminated sulfur-containing prepolymers, and e phosphine catalysts useful in aerospace sealant applications are disclosed. The compositions exhibit extended pot life, cure rapidly following activation, and provide cured sealants having improved properties useful in aerospace sealant applications.

  本发明公开了由迈克尔受体封端的含硫预聚物、硫醇封端的含硫预聚物和用于航空密封剂的膦催化剂组成的组合物。这些组合物具有更长的固化寿命，在活化后可迅速固化，并可提供性能更好的固化密封剂，适用于航空航天密封剂应用。
• Ionic liquid catalysts in sulfur-containing polymer compositions
  申请人：PRC-DeSoto International, Inc.

  公开号：US10035926B2

  公开（公告）日：2018-07-31

  Compositions comprising thiol-terminated sulfur-containing prepolymers, curing agents reactive with the thiol-terminated sulfur-containing prepolymers, and ionic liquid catalysts, useful in aerospace sealant applications are disclosed. The use of ionic liquid catalysts provides curable sealant compositions having an extended working time and a rapid cure rate.

  本发明公开了由硫醇封端含硫预聚物、与硫醇封端含硫预聚物反应的固化剂和离子液体催化剂组成的、可用于航空航天密封剂的组合物。使用离子液体催化剂可提供工作时间更长、固化速度更快的可固化密封剂组合物。
• Catalytic compositions and thiolene-based compositions with extended pot life
  申请人：PPG INDUSTRIES OHIO, INC.

  公开号：US10981158B2

  公开（公告）日：2021-04-20

  The present invention is directed to catalytic compositions and to curable compositions containing them. Catalytic compositions of the present invention consist essentially of: (i) a metal compound; and (ii) a compound different from (i) that catalyzes an addition reaction between an ethylenically unsaturated compound and a thiol, wherein said catalytic composition is essentially free of vanadium compounds. Curable compositions according to the present invention comprise: (a) a polyene, (b) a polythiol, and (c) a catalytic component, which consists of the afore-mentioned catalytic composition.

  本发明涉及催化组合物和含有它们的可固化组合物。本发明的催化组合物主要包括：(i) 金属化合物；(ii) 不同于(i)的化合物，该化合物可催化乙烯基不饱和化合物与硫醇之间的加成反应，其中所述催化组合物基本上不含钒化合物。根据本发明的可固化组合物包括：(a)聚烯，(b)聚硫醇，和(c)由上述催化组合物组成的催化组分。
• MALEIMIDE-TERMINATED SULFUR-CONTAINING POLYMERS, COMPOSITIONS THEREOF, AND USES THEREOF
  申请人：PRC-Desoto International, Inc.

  公开号：EP3063207A2

  公开（公告）日：2016-09-07