1-(1-丙基丁基)哌嗪 | 444892-66-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1-(1-丙基丁基)哌嗪
• 英文名称: 1-(1-Propyl-butyl)-piperazine
• 英文别名: 1-(1-Propylbutyl)piperazine；1-heptan-4-ylpiperazine
• CAS: 444892-66-4
• 化学式: C₁₁H₂₄N₂
• 分子量: 184.325
• InChiKey: GAMSMPMYIARKIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(4-氯苯甲酰)丙酸 、 1-(1-丙基丁基)哌嗪 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 、 二氯甲烷 为溶剂， 反应 5.5h， 生成 1-(4-Chloro-phenyl)-4-[4-(1-propyl-butyl)-piperazin-1-yl]-butane-1,4-dione
  参考文献：
  名称：

  1-Alkyl-4-acylpiperazines as a New Class of Imidazole-Free Histamine H₃ Receptor Antagonists

  摘要：

  With the aim of identifying structurally novel, centrally acting histamine H-3 antagonists, arrays of monoacyldiamines were screened. This led to the discovery of a series of 1-alkyl-4-acylpiperazines which were potent antagonists at the human histamine H-3 receptor. The most potent amides had antagonist potencies in the subnanomolar range.

  DOI：

  10.1021/jm031028z
• 作为产物：
  描述：

  4-庚酮 在 sodium cyanoborohydride 、 溶剂黄146 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 1-(1-丙基丁基)哌嗪
  参考文献：
  名称：

  1-Alkyl-4-acylpiperazines as a New Class of Imidazole-Free Histamine H₃ Receptor Antagonists

  摘要：

  With the aim of identifying structurally novel, centrally acting histamine H-3 antagonists, arrays of monoacyldiamines were screened. This led to the discovery of a series of 1-alkyl-4-acylpiperazines which were potent antagonists at the human histamine H-3 receptor. The most potent amides had antagonist potencies in the subnanomolar range.

  DOI：

  10.1021/jm031028z

文献信息

• Hydrogen barrier agent, hydrogen barrier film forming composition, hydrogen barrier film, method for producing hydrogen barrier film, and electronic element
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US11142629B2

  公开（公告）日：2021-10-12

  A hydrogen barrier agent capable of imparting hydrogen barrier performance to various materials; a hydrogen barrier film forming composition including the hydrogen barrier agent; a hydrogen barrier film including the hydrogen barrier agent; a method for producing a hydrogen barrier film, which uses the composition; and an electronic element provided with the hydrogen barrier film. A salt compound having a specific structure including an imidazolyl group is used as the hydrogen barrier agent. The composition is prepared by blending the hydrogen barrier agent into the base material component. The hydrogen barrier film is formed using the hydrogen barrier film forming composition.

  一种能使各种材料具有氢阻隔性能的氢阻隔剂；一种包括该氢阻隔剂的氢阻隔薄膜形成组合物；一种包括该氢阻隔剂的氢阻隔薄膜；一种使用该组合物生产氢阻隔薄膜的方法；以及一种带有该氢阻隔薄膜的电子元件。 氢气阻隔剂使用了一种具有特定结构的盐类化合物，其中包括咪唑基团。 该组合物是通过将阻氢剂与基础材料成分混合制备而成的。 利用氢阻隔膜形成组合物形成氢阻隔膜。
• HYDROGEN BARRIER AGENT, HYDROGEN BARRIER FILM FORMING COMPOSITION, HYDROGEN BARRIER FILM, METHOD FOR PRODUCING HYDROGEN BARRIER FILM, AND ELECTRONIC ELEMENT
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20190300674A1

  公开（公告）日：2019-10-03

  A hydrogen barrier agent capable of imparting hydrogen barrier performance to various materials; a hydrogen barrier film forming composition including the hydrogen barrier agent; a hydrogen barrier film including the hydrogen barrier agent; a method for producing a hydrogen barrier film, which uses the composition; and an electronic element provided with the hydrogen barrier film. A salt compound having a specific structure including an imidazolyl group is used as the hydrogen barrier agent. The composition is prepared by blending the hydrogen barrier agent into the base material component. The hydrogen barrier film is formed using the hydrogen barrier film forming composition.
• COMPOUND, EPOXY CURING CATALYST AND METHOD FOR PRODUCING COMPOUND
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20200283567A1

  公开（公告）日：2020-09-10

  A novel compound suitable as an epoxy curing catalyst; an epoxy curing catalyst using the compound; and a method for producing the compound. A compound represented by formula (1) in which X m+ represents an m valent counter cation, R 1 represents an aromatic group which may have a substituent; R 2 represents an alkylene group which may have a substituent; R 3 represents a halogen atom, a hydroxyl group, a mercapto group, a sulfide group, a silyl group, a silanol group, a nitro group, a nitroso group, a sulfonic acid ester group, a phosphino group, a phosphinyl group, a phosphonic acid ester group or an organic group; m represents an integer of 1 or more; n represents an integer of 0-3; and R 2 may bond with R 1 to form a cyclic structure.
• [EN] 6-MORPHOLINYL-2-PYRAZOLYL-9H-PURINE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS<br/>[FR] DÉRIVÉS DE LA 6-MORPHOLINYL-2-PYRAZOLYL-9H-PURINE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA PI3K
  申请人：DAIICHI SANKYO CO LTD

  公开号：WO2016157074A1

  公开（公告）日：2016-10-06

  The present invention relates to a pyrazole derivative of formula (I), a 5 pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, stereoisomer thereof or a deuterium form thereof, wherein, n, Y, Ra, R1, R2, R3, R4, R5 and R6 are as defined hereinafter in the specification, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. formula (I) Particularly, the present invention provides a compound of formula (I) as inhibitors of phosphatidylinositol-3-kinase (PI3K), which can be used for treating or preventing inflammatory, autoimmune, orphan and hyperproliferative disease and disorder.